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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Brusniak BMCBioinformatics2019 20.png|240px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Wang BMCMedInfoDecMak2019 19-1.png|240px]]</div>
'''"[[Journal:Laboratory information management software for engineered mini-protein therapeutic workflow|Laboratory information management software for engineered mini-protein therapeutic workflow]]"'''
'''"[[Journal:Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory|Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory]]"'''


Protein-based therapeutics are one of the fastest growing classes of novel medical interventions in areas such as cancer, infectious disease, and inflammation. Protein engineering plays an important role in the optimization of desired therapeutic properties such as reducing immunogenicity, increasing stability for storage, increasing target specificity, etc. One category of protein therapeutics is nature-inspired bioengineered cystine-dense peptides (CDPs) for various biological targets. These engineered proteins are often further modified by synthetic chemistry. For example, candidate mini-proteins can be conjugated into active small molecule drugs. We refer to modified mini-proteins as "optides" (optimized peptides). To efficiently serve the multidisciplinary lab scientists with varied therapeutic portfolio research goals in a non-commercial setting, a cost-effective, extendable [[laboratory information management system]] (LIMS) is/was needed. ('''[[Journal:Laboratory information management software for engineered mini-protein therapeutic workflow|Full article...]]''')<br />
n autoverification system for coagulation consists of a series of rules that allows normal data to be released without manual verification. With new advances in [[medical informatics]], the [[laboratory information system]] (LIS) has growing potential for the use of autoverification, allowing rapid and accurate verification of [[clinical laboratory]] tests. The purpose of the study is to develop and evaluate a LIS-based autoverification system for validation and efficiency.
 
Autoverification decision rules—including quality control, analytical error flag, critical value, limited range check, delta check, and logical check rules, as well as patient’s historical information—were integrated into the LIS. Autoverification limit ranges was constructed based on 5% and 95% percentiles. The four most commonly used coagulation assays—prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FBG)—were followed by the autoverification protocols. ('''[[Journal:Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory|Full article...]]''')<br />
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Revision as of 15:52, 11 November 2019

Fig1 Wang BMCMedInfoDecMak2019 19-1.png

"Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory"

n autoverification system for coagulation consists of a series of rules that allows normal data to be released without manual verification. With new advances in medical informatics, the laboratory information system (LIS) has growing potential for the use of autoverification, allowing rapid and accurate verification of clinical laboratory tests. The purpose of the study is to develop and evaluate a LIS-based autoverification system for validation and efficiency.

Autoverification decision rules—including quality control, analytical error flag, critical value, limited range check, delta check, and logical check rules, as well as patient’s historical information—were integrated into the LIS. Autoverification limit ranges was constructed based on 5% and 95% percentiles. The four most commonly used coagulation assays—prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FBG)—were followed by the autoverification protocols. (Full article...)

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