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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Baratta FrontPharmaco2019 10.jpg|240px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Wang BMCMedInfoDecMak2019 19-1.png|240px]]</div>
'''"[[Journal:Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes|Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes]]"'''
'''"[[Journal:Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory|Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory]]"'''


Under current legislation in Italy, using the ''[[wikipedia:Cannabis|Cannabis]]'' plant for medical purposes requires administering it orally in the form of a decoction or as ''Cannabis'' oil extract. The scientific literature reports a number of preparation methods, mainly for oils, but no study is available that compares thoroughly, from a technological viewpoint, the ''Cannabis''-based formulations currently administered to patients. With this in mind, this research work aimed to carry out specific formulation studies to design standard operating procedures for the preparation and optimization of ''Cannabis''-based galenic formulations. Both decoctions and oils were prepared under different operating conditions to identify the most efficient process for the production of formulations with a high concentration of [[wikipedia:Decarboxylation|decarboxylated]] [[wikipedia:Tetrahydrocannabinol|delta-9-tetrahydrocannabinol]] (THC) and [[wikipedia:Cannabidiol|cannabidiol]] (CBD). Regarding ''Cannabis'' oil, a new procedure has been developed that allows significantly higher recovery rates for THC and CBD compared with those for water-based extraction methods (decoction) and those for oil-based methods currently in use. ('''[[Journal:Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes|Full article...]]''')<br />
n autoverification system for coagulation consists of a series of rules that allows normal data to be released without manual verification. With new advances in [[medical informatics]], the [[laboratory information system]] (LIS) has growing potential for the use of autoverification, allowing rapid and accurate verification of [[clinical laboratory]] tests. The purpose of the study is to develop and evaluate a LIS-based autoverification system for validation and efficiency.
 
Autoverification decision rules—including quality control, analytical error flag, critical value, limited range check, delta check, and logical check rules, as well as patient’s historical information—were integrated into the LIS. Autoverification limit ranges was constructed based on 5% and 95% percentiles. The four most commonly used coagulation assays—prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FBG)—were followed by the autoverification protocols. ('''[[Journal:Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory|Full article...]]''')<br />
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Revision as of 15:52, 11 November 2019

Fig1 Wang BMCMedInfoDecMak2019 19-1.png

"Design and evaluation of a LIS-based autoverification system for coagulation assays in a core clinical laboratory"

n autoverification system for coagulation consists of a series of rules that allows normal data to be released without manual verification. With new advances in medical informatics, the laboratory information system (LIS) has growing potential for the use of autoverification, allowing rapid and accurate verification of clinical laboratory tests. The purpose of the study is to develop and evaluate a LIS-based autoverification system for validation and efficiency.

Autoverification decision rules—including quality control, analytical error flag, critical value, limited range check, delta check, and logical check rules, as well as patient’s historical information—were integrated into the LIS. Autoverification limit ranges was constructed based on 5% and 95% percentiles. The four most commonly used coagulation assays—prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FBG)—were followed by the autoverification protocols. (Full article...)

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