Difference between revisions of "Template:Article of the week"

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'''"[[Journal:Defending our public biological databases as a global critical infrastructure|Defending our public biological databases as a global critical infrastructure]]"'''
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Brusniak BMCBioinformatics2019 20.png|240px]]</div>
'''"[[Journal:Laboratory information management software for engineered mini-protein therapeutic workflow|Laboratory information management software for engineered mini-protein therapeutic workflow]]"'''


Progress in modern biology is being driven, in part, by the large amounts of freely available data in public resources such as the International Nucleotide Sequence Database Collaboration (INSDC), the world's primary database of biological sequence (and related) [[information]]. INSDC and similar databases have dramatically increased the pace of fundamental biological discovery and enabled a host of innovative therapeutic, diagnostic, and forensic applications. However, as high-value, openly shared resources with a high degree of assumed trust, these repositories share compelling similarities to the early days of the internet. Consequently, as public biological databases continue to increase in size and importance, we expect that they will face the same threats as undefended cyberspace. There is a unique opportunity, before a significant breach and loss of trust occurs, to ensure they evolve with quality and security as a design philosophy rather than costly “retrofitted” mitigations. This perspective article surveys some potential quality assurance and security weaknesses in existing open [[Genomics|genomic]] and [[Proteomics|proteomic]] repositories, describes methods to mitigate the likelihood of both intentional and unintentional errors, and offers recommendations for risk mitigation based on lessons learned from [[cybersecurity]]. ('''[[Journal:Defending our public biological databases as a global critical infrastructure|Full article...]]''')<br />
Protein-based therapeutics are one of the fastest growing classes of novel medical interventions in areas such as cancer, infectious disease, and inflammation. Protein engineering plays an important role in the optimization of desired therapeutic properties such as reducing immunogenicity, increasing stability for storage, increasing target specificity, etc. One category of protein therapeutics is nature-inspired bioengineered cystine-dense peptides (CDPs) for various biological targets. These engineered proteins are often further modified by synthetic chemistry. For example, candidate mini-proteins can be conjugated into active small molecule drugs. We refer to modified mini-proteins as "optides" (optimized peptides). To efficiently serve the multidisciplinary lab scientists with varied therapeutic portfolio research goals in a non-commercial setting, a cost-effective, extendable [[laboratory information management system]] (LIMS) is/was needed. ('''[[Journal:Laboratory information management software for engineered mini-protein therapeutic workflow|Full article...]]''')<br />
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''Recently featured'':
''Recently featured'':
: ▪ [[Journal:Defending our public biological databases as a global critical infrastructure|Defending our public biological databases as a global critical infrastructure]]
: ▪ [[Journal:Determining the hospital information system (HIS) success rate: Development of a new instrument and case study|Determining the hospital information system (HIS) success rate: Development of a new instrument and case study]]
: ▪ [[Journal:Determining the hospital information system (HIS) success rate: Development of a new instrument and case study|Determining the hospital information system (HIS) success rate: Development of a new instrument and case study]]
: ▪ [[Journal:Smart information systems in cybersecurity: An ethical analysis|Smart information systems in cybersecurity: An ethical analysis]]
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Revision as of 16:28, 29 July 2019

Fig1 Brusniak BMCBioinformatics2019 20.png

"Laboratory information management software for engineered mini-protein therapeutic workflow"

Protein-based therapeutics are one of the fastest growing classes of novel medical interventions in areas such as cancer, infectious disease, and inflammation. Protein engineering plays an important role in the optimization of desired therapeutic properties such as reducing immunogenicity, increasing stability for storage, increasing target specificity, etc. One category of protein therapeutics is nature-inspired bioengineered cystine-dense peptides (CDPs) for various biological targets. These engineered proteins are often further modified by synthetic chemistry. For example, candidate mini-proteins can be conjugated into active small molecule drugs. We refer to modified mini-proteins as "optides" (optimized peptides). To efficiently serve the multidisciplinary lab scientists with varied therapeutic portfolio research goals in a non-commercial setting, a cost-effective, extendable laboratory information management system (LIMS) is/was needed. (Full article...)

Recently featured:

▪ Defending our public biological databases as a global critical infrastructure
▪ Determining the hospital information system (HIS) success rate: Development of a new instrument and case study
▪ Smart information systems in cybersecurity: An ethical analysis
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