Journal:Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes
| Full article title | Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes |
|---|---|
| Journal | Frontiers in Pharmacology |
| Author(s) | Baratta, Francesca; Simiele, Marco; Pignata, Irene; Enri, Lorenzo R.; Torta, Riccardo; De Luca, Anna; Collino, Massimo; D'Avolio, Antonio; Brusa, Paola |
| Author affiliation(s) | University of Turin, Amedeo di Savoia Hospital, CoQua Lab S.r.l., Città della Salute |
| Primary contact | Email: francesca dot baratta at unito dot it |
| Editors | Kirsch, Wolff M. |
| Year published | 2019 |
| Volume and issue | 10 |
| Page(s) | 701 |
| DOI | 10.3389/fphar.2019.00701 |
| ISSN | 1663-9812 |
| Distribution license | Creative Commons Attribution 4.0 International |
| Website | https://www.frontiersin.org/articles/10.3389/fphar.2019.00701/full |
| Download | https://www.frontiersin.org/articles/10.3389/fphar.2019.00701/pdf (PDF) |
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Abstract
Under current legislation in Italy, Cannabis for medical purposes may be administered orally in the form of decoction or Cannabis oil extract. The scientific literature reports a number of preparation methods, mainly for oils, but no study is available that compares thoroughly, from a technological viewpoint, the Cannabis-based formulations currently administered to patients. With this in mind, this research work aimed to carry out specific formulation studies to design standard operating procedures for the preparation and optimization of Cannabis-based galenic formulations. Both decoctions and oils were prepared under different operating conditions to identify the most efficient process for the production of formulations with a high concentration of decarboxylated delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Regarding Cannabis oil, a new procedure has been developed that allows significantly higher recovery rates for THC and CBD compared with those for water-based extraction methods (decoction) and those for oil-based methods currently in use. Moreover, based on the results, it is possible to affirm that the prescription of Cannabis-based decoctions should not be the recommended first-choice solution for therapy, considering the low concentration of THC and CBD and, consequently, the high volume of decoction that the patient would have to ingest.
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Notes
This presentation is faithful to the original, with only a few minor changes to presentation. Some grammar and punctuation was cleaned up to improve readability. In some cases important information was missing from the references, and that information was added. The original article listed references alphabetically; this version, by design, lists them in order of appearance.
