Vendor:Sapio Sciences, LLC
| Type | Limited Liability Company |
|---|---|
| Industry | Laboratory informatics |
| Headquarters |
Inner Harbor Center 400 E. Pratt Street Suite 800 Baltimore, Maryland, U.S. |
| Area served | U.S. |
| Products |
Products list
|
| Website | SapioSciences.com |
Sapio Sciences, LLC develops and distributes laboratory informatics software solutions.
History
Sapio Sciences is a software vendor that develops and markets the Exemplar product line. Exemplar is a versatile software tool that encompasses Laboratory Information Management, Electronic Laboratory Notebook, Molecular Diagnostics, Biomarker Discovery and Data Management in a single framework.
Corporate history
Sapio Sciences was originally founded in 2004 to develop software tools to address the growing genotyping need for tools to assist in analyzing genetics data, particularly in relation to Genome Wide Association Studies. Sapio's first product was Exemplar Analytics, which ultimately incorporated over 50 different algorithms and was utilized in numerous published papers in prestigious journals.[1][2][3][4][5] Sapio's was subsequently approached by several customers to develop a LIMS solution that would provide a greater level of flexibility and configurability than traditional LIMS solutions on the market. This led to the development of Exemplar LIMS and its introduction in June 2007.
Technology and products
Product details
Since its original introduction in 2007, Exemplar has evolved into more than a LIMS solution. Sapio introduced its Workflow Engine in 2008, which enabled Exemplar customers to easily implement step by step, detailed processes in Exemplar that could track any workflow. This meant that Exemplar was able to address the Electronic Laboratory Notebook market and eliminate paper based recording of lab process information.
Exemplar subsequently added a fully configurable data model which meant that Exemplar could now track virtually any data assuming reasonable constraints on volume.[6] This has led to Exemplar being used for Scientific Data Management (SDMS) where it is used to manage large volumes of targeted assay data. Statistics have also be implemented to perform detailed analysis of scientific data within the same environment.
Role in Biomarker discovery
Sapio has made increasing inroads into Biomarker discovery at large Biotechnology and Pharmaceutical firms with the introduction of its Exemplar Biomarker Discovery solution. This offering enables a single solution for managing clinical study data, treatment groups data, subject data, sample data and assay data from diverse assays such as Immunohistochemistry, Western Blot, PCR, etc. This collective data warehouse can then be interrogated using Exemplar's built-in data mining tools to get answers to complex questions regarding the Pharmacodynamics effects of a drug. Exemplar then integrates statistical analysis tools for doing common data processing such as data normalization, but also for doing exploratory analysis such as logistic regression, ANOVA and genetic algorithms for model building. The results of these analysis can lead to proper patient profiling for personalized medicine, and can mean the difference between success or failure for new or existing drugs.
Role at Molecular Diagnostics companies
Building on its success at leading Molecular Diagnostic companies, Sapio introduced the Exemplar Dx LIMS product. Exemplar Dx is a foundational technology for MDx companies that implements a completely electronic process from test request to results. Physicians can be presented a web interface for test ordering, or test requests can be imported using the HL7 format. Kit Providers and kit fulfillment can also be handled by Exemplar when needed. Once the sample is at the lab, Exemplar fulfills its normal role for sample management and protocol tracking with an emphasis on instrument integration with leading Dx platforms like Qiagen and Beckman Coulter. Importantly, the assay data is then managed in Exemplar and the Dx companies custom algorithms can be implemented to analyze the data and produce the diagnostic report automatically. This report, once electronically signed off, is then delivered via the web, secure fax, HL7 or secure email to the requesting physician.
Product architecture
Exemplar is an n-tier product that offers both Java and web based clients. Multiple databases are supported for data storage including MySQL and Oracle.
Target markets
The general framework and adaptable nature of Exemplar has made it applicable to a broad spectrum of accounts ranging from large pharmaceuticals to university R&D departments. Exemplar is also being used in highly regulated environments such as part 11, GLP and CLIA laboratories.[7] The Exemplar family of products are focused on supporting non-profit research labs, commercial entities engaging in the discovery of biomarkers, and commercial companies applying ready-for-market molecular based diagnostics.
Features
Pricing
Additional information
References
- ↑ Shiels, A; Bennett, TM; Knopf, HL; Maraini, G; Li, A; Jiao, X; Hejtmancik, JF (2008). "The EPHA2 gene is associated with cataracts linked to chromosome 1p". Molecular vision 14: 2042–55. PMC 2582197. PMID 19005574. https://www.ncbi.nlm.nih.gov/pmc/articles/2582197.
- ↑ Davila, Sonia; Hibberd, Martin L.; Hari Dass, Ranjeeta; Wong, Hazel E. E.; Sahiratmadja, Edhyana; Bonnard, Carine; Alisjahbana, Bachti; Szeszko, Jeffrey S. et al. (2008). Gojobori, Takashi. ed. "Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis". PLoS Genetics 4 (10): e1000218. doi:10.1371/journal.pgen.1000218. PMC 2568981. PMID 18927625. https://www.ncbi.nlm.nih.gov/pmc/articles/2568981.
- ↑ Mattapallil, MJ; Sahin, A; Silver, PB; Sun, SH; Chan, CC; Remmers, EF; Hejtmancik, JF; Caspi, RR (2008). "Common genetic determinants of uveitis shared with other autoimmune disorders". Journal of immunology (Baltimore, Md. : 1950) 180 (10): 6751–9. PMC 2493541. PMID 18453595. https://www.ncbi.nlm.nih.gov/pmc/articles/2493541.
- ↑ Burgner, David; Davila, Sonia; Breunis, Willemijn B.; Ng, Sarah B.; Li, Yi; Bonnard, Carine; Ling, Ling; Wright, Victoria J. et al. (2009). Gibson, Greg. ed. "A Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease". PLoS Genetics 5 (1): e1000319. doi:10.1371/journal.pgen.1000319. PMC 2607021. PMID 19132087. https://www.ncbi.nlm.nih.gov/pmc/articles/2607021.
- ↑ Horvath, Anelia; Boikos, Sosipatros; Giatzakis, Christoforos; Robinson-White, Audrey; Groussin, Lionel; Griffin, Kurt J; Stein, Erica; Levine, Elizabeth et al. (2006). "A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia". Nature Genetics 38 (7): 794–800. doi:10.1038/ng1809. PMID 16767104.
- ↑ "Sapio Sciences Exemplar LIMS 4.0". Scientificcomputing.com. 16 June 2010. http://www.scientificcomputing.com/Products-Sapio-Sciences-Exemplar-LIMS-4.0-061510.aspx. Retrieved 2012-10-26.
- ↑ "ExonHit Bets on Sapio LIMS". Bio-IT World. http://www.bio-itworld.com/issues/2008/oct/exonhit.html. Retrieved 2012-10-26.
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