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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Bhattacharya FrontInOnc2019 9.jpg|240px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig2 Berezin PLoSCompBio23 19-12.png|240px]]</div>
'''"[[Journal:AI meets exascale computing: Advancing cancer research with large-scale high-performance computing|AI meets exascale computing: Advancing cancer research with large-scale high-performance computing]]"'''
'''"[[Journal:Ten simple rules for managing laboratory information|Ten simple rules for managing laboratory information]]"'''
 
[[Information]] is the cornerstone of [[research]], from experimental data/[[metadata]] and computational processes to complex inventories of reagents and equipment. These 10 simple rules discuss best practices for leveraging [[laboratory information management system]]s (LIMS) to transform this large information load into useful scientific findings. The development of [[mathematical model]]s that can predict the properties of biological systems is the holy grail of [[computational biology]]. Such models can be used to test biological hypotheses, guide the development of biomanufactured products, engineer new systems meeting user-defined specifications, and much more ... ('''[[Journal:Ten simple rules for managing laboratory information|Full article...]]''')<br />


The application of data science in [[cancer]] research has been boosted by major advances in three primary areas: (1) data: diversity, amount, and availability of biomedical data; (2) advances in [[artificial intelligence]] (AI) and machine learning (ML) algorithms that enable learning from complex, large-scale data; and (3) advances in computer architectures allowing unprecedented acceleration of simulation and machine learning algorithms. These advances help build ''in silico'' ML models that can provide transformative insights from data, including molecular dynamics simulations, [[Sequencing|next-generation sequencing]], omics, [[Molecular imaging|imaging]], and unstructured clinical text documents. Unique challenges persist, however, in building ML models related to cancer, including: (1) access, sharing, labeling, and integration of multimodal and multi-institutional data across different cancer types; (2) developing AI models for cancer research capable of scaling on next-generation high-performance computers; and (3) assessing robustness and reliability in the AI models. ('''[[Journal:AI meets exascale computing: Advancing cancer research with large-scale high-performance computing|Full article...]]''')<br />
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Latest revision as of 18:03, 10 June 2024

Fig2 Berezin PLoSCompBio23 19-12.png

"Ten simple rules for managing laboratory information"

Information is the cornerstone of research, from experimental data/metadata and computational processes to complex inventories of reagents and equipment. These 10 simple rules discuss best practices for leveraging laboratory information management systems (LIMS) to transform this large information load into useful scientific findings. The development of mathematical models that can predict the properties of biological systems is the holy grail of computational biology. Such models can be used to test biological hypotheses, guide the development of biomanufactured products, engineer new systems meeting user-defined specifications, and much more ... (Full article...)

Recently featured: