Difference between revisions of "Template:Article of the week"

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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 OConnor BMCInformatics2010 11-12.jpg|240px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Signoroni NatComm23 14.png|240px]]</div>
'''"[[Journal:SeqWare Query Engine: Storing and searching sequence data in the cloud|SeqWare Query Engine: Storing and searching sequence data in the cloud]]"'''
'''"[[Journal:Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology|Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology]]"'''


Since the introduction of next-generation DNA sequencers the rapid increase in [[Sequencing|sequencer]] throughput, and associated drop in costs, has resulted in more than a dozen human [[Genomics|genomes]] being resequenced over the last few years. These efforts are merely a prelude for a future in which genome resequencing will be commonplace for both biomedical research and clinical applications. The dramatic increase in sequencer output strains all facets of computational infrastructure, especially databases and query interfaces. The advent of cloud computing, and a variety of powerful tools designed to process petascale datasets, provide a compelling solution to these ever increasing demands.
Full [[laboratory automation]] is revolutionizing work habits in an increasing number of clinical [[microbiology]] facilities worldwide, generating huge streams of [[Imaging|digital images]] for interpretation. Contextually, [[deep learning]] (DL) architectures are leading to paradigm shifts in the way computers can assist with difficult visual interpretation tasks in several domains. At the crossroads of these epochal trends, we present a system able to tackle a core task in clinical microbiology, namely the global interpretation of diagnostic [[Bacteria|bacterial]] [[Cell culture|culture]] plates, including presumptive [[pathogen]] identification. This is achieved by decomposing the problem into a hierarchy of complex subtasks and addressing them with a multi-network architecture we call DeepColony ... ('''[[Journal:Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology|Full article...]]''')<br />
 
''Recently featured'':
In this work, we present the [[SeqWare]] Query Engine which has been created using modern cloud computing technologies and designed to support databasing information from thousands of genomes. Our backend implementation was built using the highly scalable, NoSQL HBase database from the Hadoop project. We also created a web-based frontend that provides both a programmatic and interactive query interface and integrates with widely used genome browsers and tools. ('''[[Journal:SeqWare Query Engine: Storing and searching sequence data in the cloud|Full article...]]''')<br />
{{flowlist |
 
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Latest revision as of 15:02, 3 June 2024

Fig1 Signoroni NatComm23 14.png

"Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology"

Full laboratory automation is revolutionizing work habits in an increasing number of clinical microbiology facilities worldwide, generating huge streams of digital images for interpretation. Contextually, deep learning (DL) architectures are leading to paradigm shifts in the way computers can assist with difficult visual interpretation tasks in several domains. At the crossroads of these epochal trends, we present a system able to tackle a core task in clinical microbiology, namely the global interpretation of diagnostic bacterial culture plates, including presumptive pathogen identification. This is achieved by decomposing the problem into a hierarchy of complex subtasks and addressing them with a multi-network architecture we call DeepColony ... (Full article...)
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