Difference between revisions of "Template:Article of the week"

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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig3 Panahiazar JofBiomedInformatics2017 72-8.jpg|240px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig2 Berezin PLoSCompBio23 19-12.png|240px]]</div>
'''"[[Journal:Predicting biomedical metadata in CEDAR: A study of Gene Expression Omnibus (GEO)|Predicting biomedical metadata in CEDAR: A study of Gene Expression Omnibus (GEO)]]"'''
'''"[[Journal:Ten simple rules for managing laboratory information|Ten simple rules for managing laboratory information]]"'''


A crucial and limiting factor in data reuse is the lack of accurate, structured, and complete descriptions of data, known as metadata. Towards improving the quantity and quality of metadata, we propose a novel metadata prediction framework to learn associations from existing metadata that can be used to predict metadata values. We evaluate our framework in the context of experimental metadata from the Gene Expression Omnibus (GEO). We applied four rule mining algorithms to the most common structured metadata elements (sample type, molecular type, platform, label type and organism) from over 1.3 million GEO records. We examined the quality of well supported rules from each algorithm and visualized the dependencies among metadata elements. Finally, we evaluated the performance of the algorithms in terms of accuracy, precision, recall, and F-measure. We found that PART is the best algorithm outperforming Apriori, Predictive Apriori, and Decision Table.
[[Information]] is the cornerstone of [[research]], from experimental data/[[metadata]] and computational processes to complex inventories of reagents and equipment. These 10 simple rules discuss best practices for leveraging [[laboratory information management system]]s (LIMS) to transform this large information load into useful scientific findings. The development of [[mathematical model]]s that can predict the properties of biological systems is the holy grail of [[computational biology]]. Such models can be used to test biological hypotheses, guide the development of biomanufactured products, engineer new systems meeting user-defined specifications, and much more ... ('''[[Journal:Ten simple rules for managing laboratory information|Full article...]]''')<br />


All algorithms perform significantly better in predicting class values than the majority vote classifier. We found that the performance of the algorithms is related to the dimensionality of the GEO elements. ('''[[Journal:Predicting biomedical metadata in CEDAR: A study of Gene Expression Omnibus (GEO)|Full article...]]''')<br />
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Revision as of 18:03, 10 June 2024

Fig2 Berezin PLoSCompBio23 19-12.png

"Ten simple rules for managing laboratory information"

Information is the cornerstone of research, from experimental data/metadata and computational processes to complex inventories of reagents and equipment. These 10 simple rules discuss best practices for leveraging laboratory information management systems (LIMS) to transform this large information load into useful scientific findings. The development of mathematical models that can predict the properties of biological systems is the holy grail of computational biology. Such models can be used to test biological hypotheses, guide the development of biomanufactured products, engineer new systems meeting user-defined specifications, and much more ... (Full article...)

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