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<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig1 Reid BMCInformatics2014 15.jpg|220px]]</div>
<div style="float: left; margin: 0.5em 0.9em 0.4em 0em;">[[File:Fig2 Berezin PLoSCompBio23 19-12.png|240px]]</div>
'''"[[Journal:Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline|Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline]]"'''
'''"[[Journal:Ten simple rules for managing laboratory information|Ten simple rules for managing laboratory information]]"'''


Massively parallel DNA sequencing generates staggering amounts of data. Decreasing cost, increasing throughput, and improved annotation have expanded the diversity of genomics applications in research and clinical practice. This expanding scale creates analytical challenges: accommodating peak compute demand, coordinating secure access for multiple analysts, and sharing validated tools and results.
[[Information]] is the cornerstone of [[research]], from experimental data/[[metadata]] and computational processes to complex inventories of reagents and equipment. These 10 simple rules discuss best practices for leveraging [[laboratory information management system]]s (LIMS) to transform this large information load into useful scientific findings. The development of [[mathematical model]]s that can predict the properties of biological systems is the holy grail of [[computational biology]]. Such models can be used to test biological hypotheses, guide the development of biomanufactured products, engineer new systems meeting user-defined specifications, and much more ... ('''[[Journal:Ten simple rules for managing laboratory information|Full article...]]''')<br />


To address these challenges, we have developed the Mercury analysis pipeline and deployed it in local hardware and the Amazon Web Services cloud via the DNAnexus platform. Mercury is an automated, flexible, and extensible analysis workflow that provides accurate and reproducible genomic results at scales ranging from individuals to large cohorts.
''Recently featured'':
 
{{flowlist |
By taking advantage of cloud computing and with Mercury implemented on the DNAnexus platform, we have demonstrated a powerful combination of a robust and fully validated software pipeline and a scalable computational resource that, to date, we have applied to more than 10,000 whole genome and whole exome samples. ('''[[Journal:Launching genomics into the cloud: Deployment of Mercury, a next generation sequence analysis pipeline|Full article...]]''')<br />
* [[Journal:Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology|Hierarchical AI enables global interpretation of culture plates in the era of digital microbiology]]
 
* [[Journal:Critical analysis of the impact of AI on the patient–physician relationship: A multi-stakeholder qualitative study|Critical analysis of the impact of AI on the patient–physician relationship: A multi-stakeholder qualitative study]]
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* [[Journal:Judgements of research co-created by generative AI: Experimental evidence|Judgements of research co-created by generative AI: Experimental evidence]]
''Recently featured'': [[Journal:Benefits of the community for partners of open source vendors|Benefits of the community for partners of open source vendors]], [[Journal:adLIMS: A customized open source software that allows bridging clinical and basic molecular research studies|adLIMS: A customized open source software that allows bridging clinical and basic molecular research studies]], [[Journal:MendeLIMS: A web-based laboratory information management system for clinical genome sequencing|MendeLIMS: A web-based laboratory information management system for clinical genome sequencing]]
}}

Revision as of 18:03, 10 June 2024

Fig2 Berezin PLoSCompBio23 19-12.png

"Ten simple rules for managing laboratory information"

Information is the cornerstone of research, from experimental data/metadata and computational processes to complex inventories of reagents and equipment. These 10 simple rules discuss best practices for leveraging laboratory information management systems (LIMS) to transform this large information load into useful scientific findings. The development of mathematical models that can predict the properties of biological systems is the holy grail of computational biology. Such models can be used to test biological hypotheses, guide the development of biomanufactured products, engineer new systems meeting user-defined specifications, and much more ... (Full article...)

Recently featured:

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