Difference between revisions of "Capillary electrophoresis–mass spectrometry"

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'''Capillary electrophoresis–mass spectrometry''' ('''CEMS''') is an [[analytical chemistry]] technique formed by the combination of the liquid separation process of [[capillary electrophoresis]] with [[mass spectrometry]].<ref name="pmid2774189">{{cite journal |author=Loo JA, Udseth HR, Smith RD |title=Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry |journal=Anal. Biochem. |volume=179 |issue=2 |pages=404–12 |year=1989 |month=June |pmid=2774189 |doi= 10.1016/0003-2697(89)90153-X|url=}}</ref> Ions are typically formed by [[electrospray ionization]],<ref name="pmid18790125">{{cite journal |author=Maxwell EJ, Chen DD |title=Twenty years of interface development for capillary electrophoresis-electrospray ionization-mass spectrometry |journal=Anal. Chim. Acta |volume=627 |issue=1 |pages=25–33 |year=2008 |month=October |pmid=18790125 |doi=10.1016/j.aca.2008.06.034 |url=http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(08)01244-0}}</ref> but they can also be formed by [[matrix-assisted laser desorption/ionization]]<ref name="pmid8831154">{{cite journal |author=Zhang H, Caprioli RM |title=Capillary electrophoresis combined with matrix-assisted laser desorption/ionization mass spectrometry; continuous sample deposition on a matrix-precoated membrane target |journal=J Mass Spectrom |volume=31 |issue=9 |pages=1039–46 |year=1996 |month=September |pmid=8831154 |doi=10.1002/(SICI)1096-9888(199609)31:9<1039::AID-JMS398>3.0.CO;2-F |url=}}</ref> or other ionization techniques. It has applications in basic research in [[proteomics]]<ref name="pmid18704377">{{cite journal |author=Metzger J, Schanstra JP, Mischak H |title=Capillary electrophoresis-mass spectrometry in urinary proteome analysis: current applications and future developments |journal=Anal Bioanal Chem |volume= 393|issue= 5|pages= 1431–42|year=2008 |month=August |pmid=18704377 |doi=10.1007/s00216-008-2309-0}}</ref> and [[Quantitative analysis (chemistry)|quantitative analysis]] of [[biomolecule]]s<ref name="pmid16252322">{{cite journal |author=Ohnesorge J, Neusüss C, Wätzig H |title=Quantitation in capillary electrophoresis-mass spectrometry |journal=Electrophoresis |volume=26 |issue=21 |pages=3973–87 |year=2005 |month=November |pmid=16252322 |doi=10.1002/elps.200500398}}</ref> as well as in [[clinical medicine]].<ref name="pmid15747373">{{cite journal |author=Kolch W, Neusüss C, Pelzing M, Mischak H |title=Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery |journal=Mass Spectrom Rev |volume=24 |issue=6 |pages=959–77 |year=2005 |pmid=15747373 |doi=10.1002/mas.20051}}</ref><ref name="pmid19010091">{{cite journal |author=Dakna M, He Z, Yu WC, Mischak H, Kolch W |title=Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment |journal=J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |volume= 877|issue= 13|pages= 1250–8|year=2008 |month=November |pmid=19010091 |doi=10.1016/j.jchromb.2008.10.048 |url=http://linkinghub.elsevier.com/retrieve/pii/S1570-0232(08)00801-5}}</ref>
'''Capillary electrophoresis–mass spectrometry''' ('''CE-MS''') is an [[analytical chemistry]] technique formed by the combination of the liquid separation process of [[capillary electrophoresis]] with [[mass spectrometry]].<ref name="pmid2774189">{{cite journal |author=Loo JA, Udseth HR, Smith RD |title=Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry |journal=Anal. Biochem. |volume=179 |issue=2 |pages=404–12 |year=1989 |month=June |pmid=2774189 |doi= 10.1016/0003-2697(89)90153-X|url=}}</ref> Ions are typically formed by [[electrospray ionization]],<ref name="pmid18790125">{{cite journal |author=Maxwell EJ, Chen DD |title=Twenty years of interface development for capillary electrophoresis-electrospray ionization-mass spectrometry |journal=Anal. Chim. Acta |volume=627 |issue=1 |pages=25–33 |year=2008 |month=October |pmid=18790125 |doi=10.1016/j.aca.2008.06.034 |url=http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(08)01244-0}}</ref> but they can also be formed by [[matrix-assisted laser desorption/ionization]]<ref name="pmid8831154">{{cite journal |author=Zhang H, Caprioli RM |title=Capillary electrophoresis combined with matrix-assisted laser desorption/ionization mass spectrometry; continuous sample deposition on a matrix-precoated membrane target |journal=J Mass Spectrom |volume=31 |issue=9 |pages=1039–46 |year=1996 |month=September |pmid=8831154 |doi=10.1002/(SICI)1096-9888(199609)31:9<1039::AID-JMS398>3.0.CO;2-F |url=}}</ref> or other ionization techniques. It has applications in basic research in [[proteomics]]<ref name="pmid18704377">{{cite journal |author=Metzger J, Schanstra JP, Mischak H |title=Capillary electrophoresis-mass spectrometry in urinary proteome analysis: current applications and future developments |journal=Anal Bioanal Chem |volume= 393|issue= 5|pages= 1431–42|year=2008 |month=August |pmid=18704377 |doi=10.1007/s00216-008-2309-0}}</ref> and [[Quantitative analysis (chemistry)|quantitative analysis]] of [[biomolecule]]s<ref name="pmid16252322">{{cite journal |author=Ohnesorge J, Neusüss C, Wätzig H |title=Quantitation in capillary electrophoresis-mass spectrometry |journal=Electrophoresis |volume=26 |issue=21 |pages=3973–87 |year=2005 |month=November |pmid=16252322 |doi=10.1002/elps.200500398}}</ref> as well as in [[clinical medicine]].<ref name="pmid15747373">{{cite journal |author=Kolch W, Neusüss C, Pelzing M, Mischak H |title=Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery |journal=Mass Spectrom Rev |volume=24 |issue=6 |pages=959–77 |year=2005 |pmid=15747373 |doi=10.1002/mas.20051}}</ref><ref name="pmid19010091">{{cite journal |author=Dakna M, He Z, Yu WC, Mischak H, Kolch W |title=Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment |journal=J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |volume= 877|issue= 13|pages= 1250–8|year=2008 |month=November |pmid=19010091 |doi=10.1016/j.jchromb.2008.10.048 |url=http://linkinghub.elsevier.com/retrieve/pii/S1570-0232(08)00801-5}}</ref>


==See also==
==See also==

Revision as of 18:49, 27 September 2011

Capillary electrophoresis–mass spectrometry (CE-MS) is an analytical chemistry technique formed by the combination of the liquid separation process of capillary electrophoresis with mass spectrometry.[1] Ions are typically formed by electrospray ionization,[2] but they can also be formed by matrix-assisted laser desorption/ionization[3] or other ionization techniques. It has applications in basic research in proteomics[4] and quantitative analysis of biomolecules[5] as well as in clinical medicine.[6][7]

See also

References

  1. ↑ Loo JA, Udseth HR, Smith RD (June 1989). "Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry". Anal. Biochem. 179 (2): 404–12. doi:10.1016/0003-2697(89)90153-X. PMID 2774189. 
  2. ↑ Maxwell EJ, Chen DD (October 2008). "Twenty years of interface development for capillary electrophoresis-electrospray ionization-mass spectrometry". Anal. Chim. Acta 627 (1): 25–33. doi:10.1016/j.aca.2008.06.034. PMID 18790125. http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(08)01244-0. 
  3. ↑ Zhang H, Caprioli RM (September 1996). "Capillary electrophoresis combined with matrix-assisted laser desorption/ionization mass spectrometry; continuous sample deposition on a matrix-precoated membrane target". J Mass Spectrom 31 (9): 1039–46. doi:10.1002/(SICI)1096-9888(199609)31:9<1039::AID-JMS398>3.0.CO;2-F. PMID 8831154. 
  4. ↑ Metzger J, Schanstra JP, Mischak H (August 2008). "Capillary electrophoresis-mass spectrometry in urinary proteome analysis: current applications and future developments". Anal Bioanal Chem 393 (5): 1431–42. doi:10.1007/s00216-008-2309-0. PMID 18704377. 
  5. ↑ Ohnesorge J, Neusüss C, Wätzig H (November 2005). "Quantitation in capillary electrophoresis-mass spectrometry". Electrophoresis 26 (21): 3973–87. doi:10.1002/elps.200500398. PMID 16252322. 
  6. ↑ Kolch W, Neusüss C, Pelzing M, Mischak H (2005). "Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery". Mass Spectrom Rev 24 (6): 959–77. doi:10.1002/mas.20051. PMID 15747373. 
  7. ↑ Dakna M, He Z, Yu WC, Mischak H, Kolch W (November 2008). "Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: A critical assessment". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877 (13): 1250–8. doi:10.1016/j.jchromb.2008.10.048. PMID 19010091. http://linkinghub.elsevier.com/retrieve/pii/S1570-0232(08)00801-5. 
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