Difference between revisions of "User:Shawndouglas/sandbox/sublevel4"

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[[File:COVID-19 vaccine vial AstraZenaca 2021 (UK).jpg|right|250px]]While testing for [[SARS-CoV-2]], the virus that causes [[COVID-19]], is technically a part of clinical diagnostics, it integrates aspects of other lab types, such as clinical pathology and molecular diagnostics. As such, it shouldn’t be surprising that an effective clinical diagnostics LIMS built for COVID-19 testing should include a few unique features outside of a generic clinical LIMS solution. This becomes even more obvious when you consider the mandatory reporting requirements, specialist workflows, and demanding turn-around time (TAT) and accuracy requirements of testing patients for COVID-19.
[[File:Toxicology Research at FDA (NCTR 1404) (6008498003).jpg|right|250px]]Test types in a toxicology lab will vary based on the lab’s focus, making the need for a LIMS that is flexible to the demands of toxicology labs essential. For example, toxicity testing on research animals may involve testing for acute toxicity, subacute toxicity, short-term subchronic toxicity, long-term chronic toxicity, reproductive toxicity, developmental toxicity, mutagenicity assays, irritation, allergic reaction, inhalation and immunotoxicity.<ref name="EatonGeneral10">{{cite book |url=https://books.google.com/books?id=jzCAKsa2CpMC&pg=PA1 |chapter=Chapter 1.01 General Overview of Toxicology |title=Comprehensive Toxicology |author=Eaton, D.L.; Gallagher, E.P. |editor=McQueen, C.A. |publisher=Elsevier |edition=2nd |pages=1–46 |year=2010 |isbn=9780080468686}}</ref> However, diagnostic testing will involve testing for drugs of abuse, poisons and heavy metals, or other toxicants. Pharmacogenetic testing may also be performed to develop dosing regiments for a specific drug.<ref name="ARUPClin19">{{cite web |url=https://arupconsult.com/content/clinical-toxicology-testing |title=Clinical Toxicology Testing |work=ARUP Consult |publisher=ARUP Laboratories |date=June 2021 |accessdate=18 November 2021}}</ref><ref name="SofronescuPurpose18">{{cite web |url=https://www.aacc.org/cln/articles/2018/december/purpose-driven-toxicology-services-the-key-to-financial-success-and-client-confidence |title=Purpose-driven Toxicology Services: The Key to Financial Success and Client Confidence |author=Sofronescu, A.G. |work=Clinical Laboratory News |publisher=American Association for Clinical Chemistry |date=01 December 2018 |accessdate=09 March 2022}}</ref> Given the broad array of specialty analyses and workflows described, it makes sense that the toxicology LIMS will have to address these specific needs.


In addition to the essential features of a standard LIMS, the COVID-19 lab will also be looking for a system that can (or allows users to)<ref name="DouglasCOVID21">{{cite book |url=https://www.limswiki.org/index.php/LII:COVID-19_Testing,_Reporting,_and_Information_Management_in_the_Laboratory/Workflow_and_information_management_for_COVID-19_(and_other_respiratory_diseases) |chapter=4. Workflow and information management for COVID-19 (and other respiratory diseases) |title=COVID-19 Testing, Reporting, and Information Management in the Laboratory |author=Douglas, S.E. |date=September 2021}}</ref>:
In addition to the essential features of a standard LIMS, the toxicology lab will also be looking for a system that can (or allows users to)<ref name="APEasyFeatures20">{{cite web |url=https://easytoxicology.com/features/ |archiveurl=https://web.archive.org/web/20201028074209/https://easytoxicology.com/features/ |title=Easytox: Features |publisher=AP Easy Software Solutions |date=2020 |archivedate=28 October 2020 |accessdate=18 November 2021}}</ref><ref name="DataUnlimitedLIMSSol20">{{cite web |url=http://www.duii.com/products/starfruit-toxicology/ |title=Starfruit Toxicology |publisher=Data Unlimited International, Inc |date=2021 |accessdate=18 November 2021}}</ref><ref name="LabLynxToxicology20">{{cite web |url=https://lablynx.com/toxicology/ |title=Toxicology LIMS |publisher=LabLynx, Inc |date=2021 |accessdate=18 November 2021}}</ref><ref name="DTPMOnlineData20">{{cite web |url=https://www.dtpm.com/online-data-management/ |title=Online Data Management |publisher=DTPM, Inc |date=2021 |accessdate=18 November 2021}}</ref><ref name="OrchardPain20">{{cite web |url=https://www.orchardsoft.com/solutions/pain-management-toxicology-labs/ |title=Pain Management & Toxicology Labs |publisher=Orchard Software Corporation |date=2021 |accessdate=18 November 2021}}</ref>:


* Conduct the specialty functions found in a clinical pathology LIMS.
* Support customizable drug panels and tests.
* Conduct the specialty functions found in a molecular diagnostics and cytogenetics LIMS.
* Support reference lab activities.
* Provide a flexible provider portal that includes disease-specific checks for test necessity.
* Track prescribed medicines and associated history.
* Support a wide variety of user, provider and patient data.
* Provide management for compounds and compound grouping.
* Provide a clear preregistration module that can capture critical patient and facility information, as well as national reporting questions.
* Provide medication-based compliance monitoring and interpretive reporting on it.
* Support queue-based specimen tracking.
* Provide decision-support rules for pain management and toxicology.
* Provide default assays and workflows for SARS-CoV-2 testing.
* Provide toxicology-specific reporting formats.
* Set up custom workflows for unique SARS-CoV-2 testing.
* Manage drug court cases associated with testing.
* Set up automatic reflex testing.
* Interface with most popular complex and point-of-care instruments used in COVID-19 testing.
* Integrate with mandatory results reporting systems and EHRs.
* Ensure efficient, native report delivery via email, fax or provider portal.
* Provide a customizable dashboard that can display disease-specific data and information.


==References==
==References==
{{Reflist}}
{{Reflist|colwidth=30em}}

Revision as of 19:13, 9 March 2022

Toxicology Research at FDA (NCTR 1404) (6008498003).jpg

Test types in a toxicology lab will vary based on the lab’s focus, making the need for a LIMS that is flexible to the demands of toxicology labs essential. For example, toxicity testing on research animals may involve testing for acute toxicity, subacute toxicity, short-term subchronic toxicity, long-term chronic toxicity, reproductive toxicity, developmental toxicity, mutagenicity assays, irritation, allergic reaction, inhalation and immunotoxicity.[1] However, diagnostic testing will involve testing for drugs of abuse, poisons and heavy metals, or other toxicants. Pharmacogenetic testing may also be performed to develop dosing regiments for a specific drug.[2][3] Given the broad array of specialty analyses and workflows described, it makes sense that the toxicology LIMS will have to address these specific needs.

In addition to the essential features of a standard LIMS, the toxicology lab will also be looking for a system that can (or allows users to)[4][5][6][7][8]:

  • Support customizable drug panels and tests.
  • Support reference lab activities.
  • Track prescribed medicines and associated history.
  • Provide management for compounds and compound grouping.
  • Provide medication-based compliance monitoring and interpretive reporting on it.
  • Provide decision-support rules for pain management and toxicology.
  • Provide toxicology-specific reporting formats.
  • Manage drug court cases associated with testing.

References

  1. ↑ Eaton, D.L.; Gallagher, E.P. (2010). "Chapter 1.01 General Overview of Toxicology". In McQueen, C.A.. Comprehensive Toxicology (2nd ed.). Elsevier. pp. 1–46. ISBN 9780080468686. https://books.google.com/books?id=jzCAKsa2CpMC&pg=PA1. 
  2. ↑ "Clinical Toxicology Testing". ARUP Consult. ARUP Laboratories. June 2021. https://arupconsult.com/content/clinical-toxicology-testing. Retrieved 18 November 2021. 
  3. ↑ Sofronescu, A.G. (1 December 2018). "Purpose-driven Toxicology Services: The Key to Financial Success and Client Confidence". Clinical Laboratory News. American Association for Clinical Chemistry. https://www.aacc.org/cln/articles/2018/december/purpose-driven-toxicology-services-the-key-to-financial-success-and-client-confidence. Retrieved 09 March 2022. 
  4. ↑ "Easytox: Features". AP Easy Software Solutions. 2020. Archived from the original on 28 October 2020. https://web.archive.org/web/20201028074209/https://easytoxicology.com/features/. Retrieved 18 November 2021. 
  5. ↑ "Starfruit Toxicology". Data Unlimited International, Inc. 2021. http://www.duii.com/products/starfruit-toxicology/. Retrieved 18 November 2021. 
  6. ↑ "Toxicology LIMS". LabLynx, Inc. 2021. https://lablynx.com/toxicology/. Retrieved 18 November 2021. 
  7. ↑ "Online Data Management". DTPM, Inc. 2021. https://www.dtpm.com/online-data-management/. Retrieved 18 November 2021. 
  8. ↑ "Pain Management & Toxicology Labs". Orchard Software Corporation. 2021. https://www.orchardsoft.com/solutions/pain-management-toxicology-labs/. Retrieved 18 November 2021. 
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