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* ''Presymptomatic and asymptomatic virus shedding'': As mentioned in the previous point, carriers can be contagious during the presymptomatic phase of the disease, and even while remaining symptom-free.<ref name="MandavilliInfected20" /><ref name="MockAsymptom20" /><ref name="YuenSARS20">{{cite journal |title=SARS-CoV-2 and COVID-19: The most important research questions |journal=Cell & Bioscience |author=Yuen, K.-S.; Fung, S.-Y.; Chan, C.-P.; Jin, D.-Y. |volume=10 |at=40 |year=2020 |doi=10.1186/s13578-020-00404-4 |pmid=32190290 |pmc=PMC7074995}}</ref><ref name="DiamondAsympt20">{{cite web |url=https://www.infectioncontroltoday.com/covid-19/asymptomatic-carriers-covid-19-make-it-tough-target |title=Asymptomatic Carriers of COVID-19 Make It Tough to Target |author=Diamond, F. |work=Infection Control Today |date=17 March 2020 |accessdate=01 April 2020}}</ref> This contagion is a result of what's called [[viral shedding]], when the virus moves from cell to cell following successful reproduction. When the virus is in this state, it can be actively found in a carrier's body fluids, excrement, and other sources. Depending on the virus, the virus can then be introduced to another person via those sources. In the case of COVID-19, the route of transmission is still being studied<ref name="JordanEnviron20">{{cite web |url=https://news.stanford.edu/2020/03/26/understanding-spread-covid-19/ |title=Environmental engineers at Stanford discuss how to identify factors affecting COVID-19 transmission |author=Jordan, R. |work=Stanford News |date=26 March 2020 |accessdate=01 April 2020}}</ref><ref name="GreenfieldboyceWHO20">{{cite web |url=https://www.npr.org/2020/03/28/823292062/who-reviews-available-evidence-on-coronavirus-transmission-through-air |title=WHO Reviews 'Current' Evidence On Coronavirus Transmission Through Air |author=Greenfieldboyce, N. |work=NPR |date=28 March 2020 |accessdate=01 April 2020}}</ref>, though water droplets (from sneezes, cough, talking, etc.) and potentially even aerosolized water droplets (water droplets from the body that have become fine spray or suspension in the air).<ref name="GreenfieldboyceWHO20" /> This initial uncertainty of transmission routes, along with mixed messages about masks and their effectiveness for COVID-19<ref name="GreenfieldboyceWHO20" /><ref name="CSTEditorialIgnore31">{{cite web |url=https://chicago.suntimes.com/2020/3/31/21200144/coronavirus-covid-19-masks-wear-cdc-pritzker-trump-public-health-virus-face-cough-sneeze |title=https://chicago.suntimes.com/2020/3/31/21200144/coronavirus-covid-19-masks-wear-cdc-pritzker-trump-public-health-virus-face-cough-sneeze |title=Ignore the mixed messages and wear that mask |author=Chicago Sun Times Editorial Board |work=Chicago Sun Times |date=31 March 2020 |accessdate=01 April 2020}}</ref><ref name="MulhollandToMask20">{{cite web |url=http://www.rfi.fr/en/international/20200329-to-mask-or-not-to-mask-mixed-messages-in-a-time-of-coronavirus-crisis-france-covid-19-spread-droplets |title=To mask or not to mask: mixed messages in a time of crisis |author=Mulholland, J. |work=RFI |date=29 March 2020 |accessdate=01 April 2020}}</ref>, makes social distancing an even stronger necessity to limit community transmission of the disease.
* ''Presymptomatic and asymptomatic virus shedding'': As mentioned in the previous point, carriers can be contagious during the presymptomatic phase of the disease, and even while remaining symptom-free.<ref name="MandavilliInfected20" /><ref name="MockAsymptom20" /><ref name="YuenSARS20">{{cite journal |title=SARS-CoV-2 and COVID-19: The most important research questions |journal=Cell & Bioscience |author=Yuen, K.-S.; Fung, S.-Y.; Chan, C.-P.; Jin, D.-Y. |volume=10 |at=40 |year=2020 |doi=10.1186/s13578-020-00404-4 |pmid=32190290 |pmc=PMC7074995}}</ref><ref name="DiamondAsympt20">{{cite web |url=https://www.infectioncontroltoday.com/covid-19/asymptomatic-carriers-covid-19-make-it-tough-target |title=Asymptomatic Carriers of COVID-19 Make It Tough to Target |author=Diamond, F. |work=Infection Control Today |date=17 March 2020 |accessdate=01 April 2020}}</ref> This contagion is a result of what's called [[viral shedding]], when the virus moves from cell to cell following successful reproduction. When the virus is in this state, it can be actively found in a carrier's body fluids, excrement, and other sources. Depending on the virus, the virus can then be introduced to another person via those sources. In the case of COVID-19, the route of transmission is still being studied<ref name="JordanEnviron20">{{cite web |url=https://news.stanford.edu/2020/03/26/understanding-spread-covid-19/ |title=Environmental engineers at Stanford discuss how to identify factors affecting COVID-19 transmission |author=Jordan, R. |work=Stanford News |date=26 March 2020 |accessdate=01 April 2020}}</ref><ref name="GreenfieldboyceWHO20">{{cite web |url=https://www.npr.org/2020/03/28/823292062/who-reviews-available-evidence-on-coronavirus-transmission-through-air |title=WHO Reviews 'Current' Evidence On Coronavirus Transmission Through Air |author=Greenfieldboyce, N. |work=NPR |date=28 March 2020 |accessdate=01 April 2020}}</ref>, though water droplets (from sneezes, cough, talking, etc.) and potentially even aerosolized water droplets (water droplets from the body that have become fine spray or suspension in the air).<ref name="GreenfieldboyceWHO20" /> This initial uncertainty of transmission routes, along with mixed messages about masks and their effectiveness for COVID-19<ref name="GreenfieldboyceWHO20" /><ref name="CSTEditorialIgnore31">{{cite web |url=https://chicago.suntimes.com/2020/3/31/21200144/coronavirus-covid-19-masks-wear-cdc-pritzker-trump-public-health-virus-face-cough-sneeze |title=https://chicago.suntimes.com/2020/3/31/21200144/coronavirus-covid-19-masks-wear-cdc-pritzker-trump-public-health-virus-face-cough-sneeze |title=Ignore the mixed messages and wear that mask |author=Chicago Sun Times Editorial Board |work=Chicago Sun Times |date=31 March 2020 |accessdate=01 April 2020}}</ref><ref name="MulhollandToMask20">{{cite web |url=http://www.rfi.fr/en/international/20200329-to-mask-or-not-to-mask-mixed-messages-in-a-time-of-coronavirus-crisis-france-covid-19-spread-droplets |title=To mask or not to mask: mixed messages in a time of crisis |author=Mulholland, J. |work=RFI |date=29 March 2020 |accessdate=01 April 2020}}</ref>, makes social distancing an even stronger necessity to limit community transmission of the disease.


* ''High viral loads and cardiovascular issues'': Coronaviruses and their accompanying respiratory infections are known to complicate issues of the cardiovascular system, which in turn may "increase the incidence and severity" of infectious diseases such as SARS and COVID-19.<ref name="MadjidPotent20">{{cite journal |title=Potential Effects of Coronaviruses on the Cardiovascular System |journal=JAMA Cardiology |author=Madjid, M.; Safavi-Naeini, P.; Solomon, S.D. |year=2020 |doi=10.1001/jamacardio.2020.1286 |pmid=32219363}}</ref><ref name="XiongCorona20">{{cite journal |title=Coronaviruses and the cardiovascular system: acute and long-term implications |journal=European Heart Journal |author=Xiong, T.-Y.; Redwood, S.; Prendergast, B.; Chen, M. |at=ehaa231 |year=2020 |doi=10.1093/eurheartj/ehaa231 |pmid=32186331}}</ref><ref name="DrigginCardio20">{{cite journal |title=Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic |journal=Journal of the American College of Cardiology |author=Driggin, E.; Madhavan, M.V.; Bikdeli, B. et al. |year=2020 |doi=10.1016/j.jacc.2020.03.031 |pmid=32201335}}</ref> While the exact cardiac effect COVID-19 has on patients is still unknown, suspicion is those with "hypertension, diabetes, and diagnosed cardiovascular disease" may be more prone to having cardiovascular complications from the disease.<ref name="OttoCardiac20">{{cite web |url=https://www.the-hospitalist.org/hospitalist/article/219645/coronavirus-updates/cardiac-symptoms-can-be-first-sign-covid-19 |title=Cardiac symptoms can be first sign of COVID-19 |author=Otto, M.A. |work=The Hospitalist |date=26 March 2020 |accessdate=01 April 2020}}</ref><ref name="ClerkinCorona20">{{cite journal |title=Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease |journal=Circulation |author=Clerkin, K.J.; Fried, J.A.; Raikhelkar, J. et al. |year=2020 |doi=10.1161/CIRCULATIONAHA.120.046941 |pmid=32200663}}</ref> Current thinking is SARS-CoV-2 either attacks heart tissues, causing myocardial dysfunction, or inevitably causes heart failure through a "cytokine storm,"<ref name="MadjidPotent20"><ref name="XiongCorona20"><ref name="OttoCardiac20" /><ref name="ClerkinCorona20" /><ref name="MehtaCOVID20">{{cite journal |title=COVID-19: Consider cytokine storm syndromes and immunosuppression |journal=The Lancet |author=Mehta, P.; McAuley, D.F.; Brown, M. et al. |volume=395 |issue=10229 |pages=P1033–34 |year=2020 |doi=10.1016/S0140-6736(20)30628-0 |pmid=32192578}}</ref>, an overproduction of signaling molecules that promote inflammation by white blood cells (leukocytes).<ref name="TisoncikInto12">{{cite journal |title=Into the eye of the cytokine storm |journal=Microbiology and Molecular Biology Reviews |author=Tisoncik, J.R.; Korth, M.J.; Simmons, C.P. et al. |volume=76 |issue=1 |pages=16–32 |year=2012 |doi=10.1128/MMBR.05015-11 |pmid=22390970 |pmc=PMC3294426}}</ref>
* ''High viral loads and cardiovascular issues'': Coronaviruses and their accompanying respiratory infections are known to complicate issues of the cardiovascular system, which in turn may "increase the incidence and severity" of infectious diseases such as SARS and COVID-19.<ref name="MadjidPotent20">{{cite journal |title=Potential Effects of Coronaviruses on the Cardiovascular System |journal=JAMA Cardiology |author=Madjid, M.; Safavi-Naeini, P.; Solomon, S.D. |year=2020 |doi=10.1001/jamacardio.2020.1286 |pmid=32219363}}</ref><ref name="XiongCorona20">{{cite journal |title=Coronaviruses and the cardiovascular system: acute and long-term implications |journal=European Heart Journal |author=Xiong, T.-Y.; Redwood, S.; Prendergast, B.; Chen, M. |at=ehaa231 |year=2020 |doi=10.1093/eurheartj/ehaa231 |pmid=32186331}}</ref><ref name="DrigginCardio20">{{cite journal |title=Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic |journal=Journal of the American College of Cardiology |author=Driggin, E.; Madhavan, M.V.; Bikdeli, B. et al. |year=2020 |doi=10.1016/j.jacc.2020.03.031 |pmid=32201335}}</ref> While the exact cardiac effect COVID-19 has on patients is still unknown, suspicion is those with "hypertension, diabetes, and diagnosed cardiovascular disease" may be more prone to having cardiovascular complications from the disease.<ref name="OttoCardiac20">{{cite web |url=https://www.the-hospitalist.org/hospitalist/article/219645/coronavirus-updates/cardiac-symptoms-can-be-first-sign-covid-19 |title=Cardiac symptoms can be first sign of COVID-19 |author=Otto, M.A. |work=The Hospitalist |date=26 March 2020 |accessdate=01 April 2020}}</ref><ref name="ClerkinCorona20">{{cite journal |title=Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease |journal=Circulation |author=Clerkin, K.J.; Fried, J.A.; Raikhelkar, J. et al. |year=2020 |doi=10.1161/CIRCULATIONAHA.120.046941 |pmid=32200663}}</ref> Current thinking is SARS-CoV-2 either attacks heart tissues, causing myocardial dysfunction, or inevitably causes heart failure through a "cytokine storm,"<ref name="MadjidPotent20" /><ref name="XiongCorona20" /><ref name="OttoCardiac20" /><ref name="ClerkinCorona20" /><ref name="MehtaCOVID20">{{cite journal |title=COVID-19: Consider cytokine storm syndromes and immunosuppression |journal=The Lancet |author=Mehta, P.; McAuley, D.F.; Brown, M. et al. |volume=395 |issue=10229 |pages=P1033–34 |year=2020 |doi=10.1016/S0140-6736(20)30628-0 |pmid=32192578}}</ref><ref name="MandavilliTheCoronaCyto20">{{cite web |url=https://www.nytimes.com/2020/04/01/health/coronavirus-cytokine-storm-immune-system.html |title=The Coronavirus Patients Betrayed by Their Own Immune Systems |author=Mandavilli, A. |work=The New York Times |date=01 April 2020 |accessdate=01 April 2020}}</ref>, an overproduction of signaling molecules that promote inflammation by white blood cells (leukocytes).<ref name="TisoncikInto12">{{cite journal |title=Into the eye of the cytokine storm |journal=Microbiology and Molecular Biology Reviews |author=Tisoncik, J.R.; Korth, M.J.; Simmons, C.P. et al. |volume=76 |issue=1 |pages=16–32 |year=2012 |doi=10.1128/MMBR.05015-11 |pmid=22390970 |pmc=PMC3294426}}</ref> What's scary is that like the 1918 Spanish flu, SARS, and other epidemics, some otherwise healthy patients' immune responses are entirely overreactive, leading to acute respiratory distress syndrome (ARDS) or heart failure.<ref name="MandavilliTheCoronaCyto20" /><ref name="BasilioANew20">{{cite web |url=https://www.mdlinx.com/internal-medicine/article/6590 |title=A new potential risk of COVID-19: Sudden cardiac death |author=Basilio, P. |work=MDLinx |date=26 March 2020 |accessdate=01 April 2020}}</ref> Overreactive immune systems and other inherent, sometimes hidden or undiagnosed conditions that may lead to cardiovascular disruption only add to the level of difficulty of properly treating COVID-19.




==References==
==References==
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{{Reflist|colwidth=30em}}

Revision as of 20:57, 1 April 2020


1. Overview of COVID-19 and its challenges

1.1 COVID-19: The terminology

A pneumonia-like outbreak was fully in process in Wuhan, located in the Hubei province of China, by December 2019. The World Health Organization (WHO) was notified by the end of the month that the cause could be a novel threat to the larger populace.[1] By the end of January, the WHO had declared the growing viral threat a Public Health Emergency of International Concern (PHEIC), an act which includes with it a need "to implement a comprehensive risk communication strategy."[2] As the disease progressed beyond its Chinese origins, public confusion slowly grew regarding the terminology surrounding the disease. Leaders at the WHO and the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses came to different naming conclusions, differing in their naming conventions and adding to the confusion.[3][4] In the end, "COVID-19" has ended up as the common disease name, caused by the SARS-CoV-2 virus, which is a member of the coronavirus family. Today, however, some still refer to the disease simply as "coronavirus," which is in errror.

This isn't the first time a disease has had a different name from its associated virus. One should look back to 1982, when the U.S. Centers for Disease Control and Prevention (CDC) gave the name "acquired immune deficiency syndrome" or "AIDS" to the disease associated with the human immunodeficiency virus (HIV) (a member of the retrovirus family).[5] It took time for the layman to get used to the terminology, and even then some still ended up mistakenly refering to the disease as "HIV."

Consistent terminology is vital to communicating technical material to a global audience.[6][7] With that in mind, it's beneficial to ensure everyone is clear one the terms used. For purposes of this guide:

  • Coronavirus disease 2019 (otherwise known as COVID-19) is the respiratory disease being discussed in this guide.
  • SARS-CoV-2 is the virus responsible for COVID-19.
  • Coronavirus (or Coronaviridae) is a family of related viruses, of which SARS-CoV-2 is a member.
  • Severe acute respiratory syndrome (otherwise known as SARS) is a different respiratory disease, which surfaced in the early 2000s, caused by a related but different type of coronavirus (SARS-CoV or SARS-CoV-1).
  • Middle East respiratory syndrome (otherwise known as MERS) is a different respiratory disease, which surfaced in 2012, caused by a related but different type of coronavirus (MERS-CoV).

1.2 COVID-19: History and impact (so far)

The first known case of COVID-19 dates back to November 2019, "according to government data seen by the South China Morning Post."[8] By the middle of December, infections were at 27, and by the end of the year the number was 266.[8] By that time, Chinease health authorities had been updated that the pneumonia-like symptoms of patients in China's Hubei province may have been the symptoms of a disease caused by a novel (new) coronavirus[8], and the WHO was notified.[1] At the start of 2020, that number grew to 381 known cases[8], jumping to more than 7,700 confirmed and 12,000 suspected cased by the end of January.[2] By that time, the WHO had convened a second meeting of its Emergency Committee to discuss the declaration of a PHEIC, saying the then-called "2019-nCoV" constituted a health emergency of international concern.[2] This spurred the publishing of WHO technical advice to other countries, with a focus on "reducing human infection, prevention of secondary transmission and international spread, and contributing to the international response."[2] However, at the same time, the virus was already beginning to spread in locations such as Australia[9], France[10], Germany[11] Italy[12], Japan[13], South Korea[14], Spain[15], the United Kingdom[16], and the United States.[17]

As the disease continued to spread in February, naming conventions came together, with the WHO declaring the disease's name "COVID-19," short for "coronavirus disease 2019."[3][4] By the end of the month, the WHO warned a "very high" likelihood the virus's spread could turn into a full pandemic.[18]

On March 11, 2020, the WHO declared the outbreak of SARS-CoV-2 a pandemic, noting more than 118,000 confirmed cases and 4,000 deaths on all continents except Antarctica.[19]


1.3 Challenges of managing the disease in the human population

COVID-19 has presented numerous societal challenges, from supply line interruptions and economic sagging to overwhelmed healthcare systems and civil disorder. However, these are largely the social, economic, and political ripple effects of a disease that has brought with it a set of inherent attributes that make it more difficult to manage in human populations than say the flu.

However, COVID-19 is not the flu, and it is indeed worse in its effects than the flu, contrary to many people's perceptions. Yes, COVID-19 and the flu have some symptom overlap. Yes, COVID-19 and the flu have some transmission type overlap. But from there it diverges. COVID-19 is different in that is more prone to be transmitted to others during the presymptomatic phase. The disease may also be transmittable in other ways, such as an airborne route, though research is ongoing. Hospitalization rates are higher, perhaps up to 10 times higher than the flu, and hospital stays are longer with COVID-19. People are dying more often from COVID-19 too, up to 10 times more often than people stricken with the flu. And of course, whereas people have been acquiring the flu vaccine yearly, limiting the percentage of the population that becomes ill, there is yet no vaccine for COVID-19, meaning everyone is susceptible.[20][21][22]

Other aspects of the disease that make this difficult to manage include:

  • Median incubation period: According to research published in Annals of Internal Medicine, the median (i.e., the central tendancy, which is less skewed than average[23]) incubation period is 5.1 days, with 97.5% of symtomatic carriers showing symptoms within 11.5 days. The authors found this to be compatible with U.S. government recommendations of monitored 14-day self-quarantines if individiuals were at risk of exposure.[24] However, many people continue to not take self-quarantines and other forms of social distancing seriously[25][26][27][28], and presymtomatic (and asymptomatic) carriers are thus more prone to spreading the virus.[29][30]
  • Presymptomatic and asymptomatic virus shedding: As mentioned in the previous point, carriers can be contagious during the presymptomatic phase of the disease, and even while remaining symptom-free.[29][30][31][32] This contagion is a result of what's called viral shedding, when the virus moves from cell to cell following successful reproduction. When the virus is in this state, it can be actively found in a carrier's body fluids, excrement, and other sources. Depending on the virus, the virus can then be introduced to another person via those sources. In the case of COVID-19, the route of transmission is still being studied[33][34], though water droplets (from sneezes, cough, talking, etc.) and potentially even aerosolized water droplets (water droplets from the body that have become fine spray or suspension in the air).[34] This initial uncertainty of transmission routes, along with mixed messages about masks and their effectiveness for COVID-19[34][35][36], makes social distancing an even stronger necessity to limit community transmission of the disease.
  • High viral loads and cardiovascular issues: Coronaviruses and their accompanying respiratory infections are known to complicate issues of the cardiovascular system, which in turn may "increase the incidence and severity" of infectious diseases such as SARS and COVID-19.[37][38][39] While the exact cardiac effect COVID-19 has on patients is still unknown, suspicion is those with "hypertension, diabetes, and diagnosed cardiovascular disease" may be more prone to having cardiovascular complications from the disease.[40][41] Current thinking is SARS-CoV-2 either attacks heart tissues, causing myocardial dysfunction, or inevitably causes heart failure through a "cytokine storm,"[37][38][40][41][42][43], an overproduction of signaling molecules that promote inflammation by white blood cells (leukocytes).[44] What's scary is that like the 1918 Spanish flu, SARS, and other epidemics, some otherwise healthy patients' immune responses are entirely overreactive, leading to acute respiratory distress syndrome (ARDS) or heart failure.[43][45] Overreactive immune systems and other inherent, sometimes hidden or undiagnosed conditions that may lead to cardiovascular disruption only add to the level of difficulty of properly treating COVID-19.


References

  1. ↑ 1.0 1.1 Hui, D.S.; Azhar, E.I.; Madani, T.A. et al. (2020). "The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China". International Journal of Infectious Diseases 91: 264–66. doi:10.1016/j.ijid.2020.01.009. PMID 31953166. 
  2. ↑ 2.0 2.1 2.2 2.3 World Health Organization (30 January 2020). "Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV)". World Health Organization. https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov). Retrieved 31 March 2020. 
  3. ↑ 3.0 3.1 Enserink, M. (12 February 2020). "Update: ‘A bit chaotic.’ Christening of new coronavirus and its disease name create confusion". Science. https://www.sciencemag.org/news/2020/02/bit-chaotic-christening-new-coronavirus-and-its-disease-name-create-confusion. Retrieved 30 March 2020. 
  4. ↑ 4.0 4.1 Jiang, S.; Shi, Z.; Shu, Y. et al. (2020). "A distinct name is needed for the new coronavirus". The Lancet 395 (10228): 949. doi:10.1016/S0140-6736(20)30419-0. PMID 32087125. 
  5. ↑ Oppenheimer, G.M. (1992). "Chapter 2: Causes, Cases, and Cohorts: The Role of Epidemiology in the Historical Construction of AIDS". In Fee, E.; Fox, D.M.. AIDS: The Making of a Chronic Disease. University of California Press. pp. 49–83. ISBN 0520077784. https://books.google.com/books?id=CmME6xfdEFAC&pg=PA49. Retrieved 31 March 2020. 
  6. ↑ Kohl, J.R. (2008). The Global English Style Guide: Writing Clear, Trnaslatable Documentation for a Global Market. SAS Institute. ISBN 9781599946573. 
  7. ↑ Megathlin, B.A.; Langford, R.S. (1991). "Controlling the Unruly: Terminology". 1991 Proceedings 38th International Technical Communication Conference: WE22–WE24. 
  8. ↑ 8.0 8.1 8.2 8.3 Ma, J. (13 March 2020). "Coronavirus: China’s first confirmed Covid-19 case traced back to November 17". South China Morning Post. https://www.scmp.com/news/china/society/article/3074991/coronavirus-chinas-first-confirmed-covid-19-case-traced-back. Retrieved 31 March 2020. 
  9. ↑ Hunt, G. (25 January 2020). "First confirmed case of novel coronavirus in Australia". Australian Department of Health. https://www.health.gov.au/ministers/the-hon-greg-hunt-mp/media/first-confirmed-case-of-novel-coronavirus-in-australia. Retrieved 31 March 2020. 
  10. ↑ Jacob, E. (24 January 2020). "Coronavirus: trois premiers cas confirmés en France, deux d’entre eux vont bien". Le Figaro. https://www.lefigaro.fr/sciences/coronavirus-trois-premiers-cas-confirmes-en-france-20200124. Retrieved 31 March 2020. 
  11. ↑ Der Spiegel (28 January 2020). "Bayerische Behörden bestätigen ersten Fall in Deutschland". https://www.spiegel.de/wissenschaft/medizin/corona-virus-erster-fall-in-deutschland-bestaetigt-a-19843b8d-8694-451f-baf7-0189d3356f99. Retrieved 31 March 2020. 
  12. ↑ Severgnini, C. (30 January 2020). "Coronavirus, primi due casi in Italia «Sono due cinesi in vacanza a Roma» Sono arrivati a Milano il 23 gennaio". Corriere della Sera. https://www.corriere.it/cronache/20_gennaio_30/coronavirus-italia-corona-9d6dc436-4343-11ea-bdc8-faf1f56f19b7.shtml. Retrieved 31 March 2020. 
  13. ↑ Sim, W. (16 January 2020). "Japan confirms first case of infection from Wuhan coronavirus; Vietnam quarantines two tourists". The Straits Times. https://www.straitstimes.com/asia/east-asia/japan-confirms-first-case-of-infection-with-new-china-coronavirus. Retrieved 31 March 2020. 
  14. ↑ Jin-woo, S. (24 January 2020). "신종 코로나바이러스 한국인 첫환자 확인". Maekyung.com. https://www.mk.co.kr/news/society/view/2020/01/80017/. Retrieved 31 March 2020. 
  15. ↑ Linde, P. (31 January 2020). "Sanidad confirma en La Gomera el primer caso de coronavirus en España". El País. https://elpais.com/sociedad/2020/01/31/actualidad/1580509404_469734.html. Retrieved 31 March 2020. 
  16. ↑ Ball, T.; Wace, C. (31 January 2020). "Hunt for contacts of coronavirus-stricken pair in York". The Times. https://www.thetimes.co.uk/article/hunt-for-contacts-of-coronavirus-stricken-pair-in-york-dh363qf8k. Retrieved 31 March 2020. 
  17. ↑ Holshue, M.L.; DeBolt, C.; Lindquist, S. et al. (2020). "First Case of 2019 Novel Coronavirus in the United States". New England Journal of Medicine 382 (10): 929–36. doi:10.1056/NEJMoa2001191. PMID 32004427. 
  18. ↑ Mulier, T. (28 February 2020). "WHO Raises Global Risk for Coronavirus to Very High". Bloomberg. https://www.bloomberg.com/news/articles/2020-02-28/who-raises-global-risk-for-coronavirus-to-very-high-from-high. Retrieved 31 March 2020. 
  19. ↑ Gumbrecht, J.; Howard, J. (11 March 2020). "WHO declares novel coronavirus outbreak a pandemic". CNN Health. https://www.cnn.com/2020/03/11/health/coronavirus-pandemic-world-health-organization/index.html. Retrieved 31 March 2020. 
  20. ↑ Huang, P. (20 March 2020). "How The Novel Coronavirus And The Flu Are Alike ... And Different". NPR: Goats and Soda. https://www.npr.org/sections/goatsandsoda/2020/03/20/815408287/how-the-novel-coronavirus-and-the-flu-are-alike-and-different. Retrieved 01 April 2020. 
  21. ↑ Resnick, B.; Animashaun, C. (18 March 2020). "Why Covid-19 is worse than the flu, in one chart". Vox. https://www.vox.com/science-and-health/2020/3/18/21184992/coronavirus-covid-19-flu-comparison-chart. Retrieved 01 April 2020. 
  22. ↑ Kumar, V. (27 March 2020). "COVID-19 has been compared to the flu. Experts say that's wrong". ABC News. https://abcnews.go.com/Health/covid-19-compared-flu-experts-wrong/story?id=69779116. Retrieved 01 April 2020. 
  23. ↑ National Water and Climate Center. "Median vs. Average to Describe Normal". U.S. Department of Agriculture. https://www.wcc.nrcs.usda.gov/normals/median_average.htm. Retrieved 01 April 2020. 
  24. ↑ Lauer, S.A.; Grantz, K.H.; Bi, Q. et al. (2020). "The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application". Annals of Internal Medicine. doi:10.7326/M20-0504. PMC PMC7081172. PMID 32150748. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081172. 
  25. ↑ Pinsker, J. (19 March 2020). "What Do You Tell Someone Who Still Won’t Stay Home?". The Atlantic. https://www.theatlantic.com/family/archive/2020/03/convince-family-take-coronavirus-seriously/608356/. Retrieved 01 April 2020. 
  26. ↑ Keating, S. (17 March 2020). "When The People You Love Can’t Accept That They Need To Stay Home". BuzzFeed News. https://www.buzzfeednews.com/article/shannonkeating/coronavirus-social-distancing-self-isolation-quarantine. Retrieved 01 April 2020. 
  27. ↑ Jackson, A. (31 March 2020). "Police are arresting and fining people for violating social distancing orders". CNN. https://www.cnn.com/2020/03/31/us/violating-coronavirus-orders-trnd/index.html. Retrieved 01 April 2020. 
  28. ↑ WFLA 8 On Your Side Staff (31 March 2020). "Hawaii police arrest visiting Tampa man for violating 14-day quarantine order". WFLA News Channel 8. https://www.wfla.com/community/health/coronavirus/hawaii-police-arrest-visiting-tampa-man-for-violating-14-day-quarantine/. Retrieved 01 April 2020. 
  29. ↑ 29.0 29.1 Mandavilli, A. (31 March 2020). "Infected but Feeling Fine: The Unwitting Coronavirus Spreaders". The New York Times. https://www.nytimes.com/2020/03/31/health/coronavirus-asymptomatic-transmission.html. Retrieved 01 April 2020. 
  30. ↑ 30.0 30.1 Mock, J. (26 March 2020). "Asymptomatic Carriers Are Fueling the COVID-19 Pandemic. Here’s Why You Don’t Have to Feel Sick to Spread the Disease". Discover. https://www.discovermagazine.com/health/asymptomatic-carriers-are-fueling-the-covid-19-pandemic-heres-why-you-dont. Retrieved 01 April 2020. 
  31. ↑ Yuen, K.-S.; Fung, S.-Y.; Chan, C.-P.; Jin, D.-Y. (2020). "SARS-CoV-2 and COVID-19: The most important research questions". Cell & Bioscience 10: 40. doi:10.1186/s13578-020-00404-4. PMC PMC7074995. PMID 32190290. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074995. 
  32. ↑ Diamond, F. (17 March 2020). "Asymptomatic Carriers of COVID-19 Make It Tough to Target". Infection Control Today. https://www.infectioncontroltoday.com/covid-19/asymptomatic-carriers-covid-19-make-it-tough-target. Retrieved 01 April 2020. 
  33. ↑ Jordan, R. (26 March 2020). "Environmental engineers at Stanford discuss how to identify factors affecting COVID-19 transmission". Stanford News. https://news.stanford.edu/2020/03/26/understanding-spread-covid-19/. Retrieved 01 April 2020. 
  34. ↑ 34.0 34.1 34.2 Greenfieldboyce, N. (28 March 2020). "WHO Reviews 'Current' Evidence On Coronavirus Transmission Through Air". NPR. https://www.npr.org/2020/03/28/823292062/who-reviews-available-evidence-on-coronavirus-transmission-through-air. Retrieved 01 April 2020. 
  35. ↑ Chicago Sun Times Editorial Board (31 March 2020). "Ignore the mixed messages and wear that mask". Chicago Sun Times. https://chicago.suntimes.com/2020/3/31/21200144/coronavirus-covid-19-masks-wear-cdc-pritzker-trump-public-health-virus-face-cough-sneeze. Retrieved 01 April 2020. 
  36. ↑ Mulholland, J. (29 March 2020). "To mask or not to mask: mixed messages in a time of crisis". RFI. http://www.rfi.fr/en/international/20200329-to-mask-or-not-to-mask-mixed-messages-in-a-time-of-coronavirus-crisis-france-covid-19-spread-droplets. Retrieved 01 April 2020. 
  37. ↑ 37.0 37.1 Madjid, M.; Safavi-Naeini, P.; Solomon, S.D. (2020). "Potential Effects of Coronaviruses on the Cardiovascular System". JAMA Cardiology. doi:10.1001/jamacardio.2020.1286. PMID 32219363. 
  38. ↑ 38.0 38.1 Xiong, T.-Y.; Redwood, S.; Prendergast, B.; Chen, M. (2020). "Coronaviruses and the cardiovascular system: acute and long-term implications". European Heart Journal: ehaa231. doi:10.1093/eurheartj/ehaa231. PMID 32186331. 
  39. ↑ Driggin, E.; Madhavan, M.V.; Bikdeli, B. et al. (2020). "Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic". Journal of the American College of Cardiology. doi:10.1016/j.jacc.2020.03.031. PMID 32201335. 
  40. ↑ 40.0 40.1 Otto, M.A. (26 March 2020). "Cardiac symptoms can be first sign of COVID-19". The Hospitalist. https://www.the-hospitalist.org/hospitalist/article/219645/coronavirus-updates/cardiac-symptoms-can-be-first-sign-covid-19. Retrieved 01 April 2020. 
  41. ↑ 41.0 41.1 Clerkin, K.J.; Fried, J.A.; Raikhelkar, J. et al. (2020). "Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease". Circulation. doi:10.1161/CIRCULATIONAHA.120.046941. PMID 32200663. 
  42. ↑ Mehta, P.; McAuley, D.F.; Brown, M. et al. (2020). "COVID-19: Consider cytokine storm syndromes and immunosuppression". The Lancet 395 (10229): P1033–34. doi:10.1016/S0140-6736(20)30628-0. PMID 32192578. 
  43. ↑ 43.0 43.1 Mandavilli, A. (1 April 2020). "The Coronavirus Patients Betrayed by Their Own Immune Systems". The New York Times. https://www.nytimes.com/2020/04/01/health/coronavirus-cytokine-storm-immune-system.html. Retrieved 01 April 2020. 
  44. ↑ Tisoncik, J.R.; Korth, M.J.; Simmons, C.P. et al. (2012). "Into the eye of the cytokine storm". Microbiology and Molecular Biology Reviews 76 (1): 16–32. doi:10.1128/MMBR.05015-11. PMC PMC3294426. PMID 22390970. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294426. 
  45. ↑ Basilio, P. (26 March 2020). "A new potential risk of COVID-19: Sudden cardiac death". MDLinx. https://www.mdlinx.com/internal-medicine/article/6590. Retrieved 01 April 2020. 
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