Translational research informatics - Revision history

Shawndouglas: Added attribution.

2014-04-24T19:38:42Z

Added attribution.

← Older revision		Revision as of 19:38, 24 April 2014
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	* [https://www.ctsacentral.org/ Clinical and Translational Science Awards]<br />		* [https://www.ctsacentral.org/ Clinical and Translational Science Awards]<br />
	* [http://www.amia.org American Medical Informatics Association (AMIA)]<br />		* [http://www.amia.org American Medical Informatics Association (AMIA)]<br />

			==Notes==

			An element or two of this article is reused from [http://en.wikipedia.org/wiki/Translational_research_informatics the Wikipedia article].

	==References==		==References==

Shawndouglas: NOTOC

2014-03-23T15:43:22Z

NOTOC

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			__NOTOC__
	'''Translational research informatics''' (TRI) (or '''translational informatics''' or TI) is a sister domain to or a sub-domain of biomedical or [[health informatics\|clinical informatics]] concerned with the application of [[Informatics (academic field)\|informatics]] theory and methods to [[translational research]]. While translational informatics has elements in common with clinical informatics, it's primarily concerned with enabling multi-disciplinary research to accelerate clinical outcomes, with clinical trials often being the natural step beyond translational research.		'''Translational research informatics''' (TRI) (or '''translational informatics''' or TI) is a sister domain to or a sub-domain of biomedical or [[health informatics\|clinical informatics]] concerned with the application of [[Informatics (academic field)\|informatics]] theory and methods to [[translational research]]. While translational informatics has elements in common with clinical informatics, it's primarily concerned with enabling multi-disciplinary research to accelerate clinical outcomes, with clinical trials often being the natural step beyond translational research.

Shawndouglas: Corrected citation year

2014-03-23T02:02:35Z

Corrected citation year

← Older revision		Revision as of 02:02, 23 March 2014
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	1. "integrated solutions to manage the: (i) logistics, (ii) data integration, and (iii) collaboration, and (iv] knowledge generation required by translational investigators and their supporting institutions."		1. "integrated solutions to manage the: (i) logistics, (ii) data integration, and (iii) collaboration, and (iv] knowledge generation required by translational investigators and their supporting institutions."
	<ref name="NDNAnderson">{{cite web \|url=http://www.neurodevnet.ca/sites/default/files/neurodevnet/download/Anderson_NeuroDevNet_0103.ppt \|archiveurl=https://web.archive.org/web/20140323010951/http://www.neurodevnet.ca/sites/default/files/neurodevnet/download/Anderson_NeuroDevNet_0103.ppt \|format=PPT \|title=Pragmatic translational informatics: Supporting collaborative science \|author=Anderson, Nicholas \|publisher=NeuroDevNet \|date=2013 \|archivedate=23 March ~~2013~~ \|accessdate=23 March ~~2013~~}}</ref>		<ref name="NDNAnderson">{{cite web \|url=http://www.neurodevnet.ca/sites/default/files/neurodevnet/download/Anderson_NeuroDevNet_0103.ppt \|archiveurl=https://web.archive.org/web/20140323010951/http://www.neurodevnet.ca/sites/default/files/neurodevnet/download/Anderson_NeuroDevNet_0103.ppt \|format=PPT \|title=Pragmatic translational informatics: Supporting collaborative science \|author=Anderson, Nicholas \|publisher=NeuroDevNet \|date=2013 \|archivedate=23 March 2014 \|accessdate=23 March 2014}}</ref>

	...or in more lengthy terms:		...or in more lengthy terms:

Shawndouglas: TRI to TI

2014-03-23T01:57:42Z

TRI to TI

← Older revision		Revision as of 01:57, 23 March 2014
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	2. "the informatics subdiscipline that is primarily concerned with the development and application of biomedical informatics theories, methods, and best practices intended to support: 1) the acquisition of knowledge and information from the preceding sources; 2) the representation of such knowledge and information in an actionable format (e.g., readily consumed and analyzed, usually through the use of computational tools and applications), and the subsequent dissemination of that knowledge or information to targeted end-users or analytical platforms; and 3) the semantic integration of disparate data sources to support the discovery and verification/validation of complex bio-marker-to-phenotype relationships that may collectively define a translational biomedical knowledge model."<ref name="PayneTI">{{cite journal \|url=http://physiolgenomics.physiology.org/content/39/3/131.full \|journal=Physiological Genomics \|year=November 2009 \|volume=39 \|issue=3 \|page=131–140 \|title=Translational informatics: enabling high-throughput research paradigms \|author=Payne, Philip R. O.; Embi, Peter J.; Sen, Chandan K. \|doi=10.1152/physiolgenomics.00050.2009 \|accessdate=22 March 2014}}</ref>		2. "the informatics subdiscipline that is primarily concerned with the development and application of biomedical informatics theories, methods, and best practices intended to support: 1) the acquisition of knowledge and information from the preceding sources; 2) the representation of such knowledge and information in an actionable format (e.g., readily consumed and analyzed, usually through the use of computational tools and applications), and the subsequent dissemination of that knowledge or information to targeted end-users or analytical platforms; and 3) the semantic integration of disparate data sources to support the discovery and verification/validation of complex bio-marker-to-phenotype relationships that may collectively define a translational biomedical knowledge model."<ref name="PayneTI">{{cite journal \|url=http://physiolgenomics.physiology.org/content/39/3/131.full \|journal=Physiological Genomics \|year=November 2009 \|volume=39 \|issue=3 \|page=131–140 \|title=Translational informatics: enabling high-throughput research paradigms \|author=Payne, Philip R. O.; Embi, Peter J.; Sen, Chandan K. \|doi=10.1152/physiolgenomics.00050.2009 \|accessdate=22 March 2014}}</ref>

	The field is relatively new, with most Clinical and Translational Science Awards (CTSAs) funding and research going into informatics tools and systems enabling the end-to-end ~~TRI~~ requirements.<ref name="CTSATools">{{cite web \|url=https://www.ctsacentral.org/reports/sharing/tools/public \|title=Tool Awareness Project \|publisher=CTSA \|accessdate=22 March 2014}}</ref>		The field is relatively new, with most Clinical and Translational Science Awards (CTSAs) funding and research going into informatics tools and systems enabling the end-to-end TI requirements.<ref name="CTSATools">{{cite web \|url=https://www.ctsacentral.org/reports/sharing/tools/public \|title=Tool Awareness Project \|publisher=CTSA \|accessdate=22 March 2014}}</ref>

	==Systems in translational informatics==		==Systems in translational informatics==

Shawndouglas: /* External sites */ Bulletss

2014-03-23T01:54:21Z

External sites: Bulletss

← Older revision		Revision as of 01:54, 23 March 2014
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	==External sites==		==External sites==
	[https://www.ctsacentral.org/ Clinical and Translational Science Awards]<br />		* [https://www.ctsacentral.org/ Clinical and Translational Science Awards]<br />
	[http://www.amia.org American Medical Informatics Association (AMIA)]<br />		* [http://www.amia.org American Medical Informatics Association (AMIA)]<br />

	==References==		==References==

Shawndouglas: Updated total article.

2014-03-23T01:53:37Z

Updated total article.

← Older revision		Revision as of 01:53, 23 March 2014
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	''(~~This article was taken from Wikipedia~~)''		'''Translational research informatics''' (TRI) (or '''translational informatics''' or TI) is a sister domain to or a sub-domain of biomedical or [[health informatics\|clinical informatics]] concerned with the application of [[Informatics (academic field)\|informatics]] theory and methods to [[translational research]]. While translational informatics has elements in common with clinical informatics, it's primarily concerned with enabling multi-disciplinary research to accelerate clinical outcomes, with clinical trials often being the natural step beyond translational research.

	~~'''~~Translational ~~Research Informatics''' (TRI) is a sister domain to or a sub-domain of Biomedical~~ informatics or Medical Informatics concerned with the application of [[Informatics (academic field)\|informatics]] theory and methods to translational research. There is some overlap with the related domain of Clinical Research Informatics, but TRI is more concerned with enabling multi-disciplinary research to accelerate clinical outcomes, with clinical trials often being the natural step beyond translational research.		Translational research informatics can be described in several different ways.

	~~Translational Research as defined~~ by ~~the National Institutes of Health [~~http://www.~~nih~~.~~gov~~/~~] includes two areas of translation~~. ~~One is the process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans~~. ~~The second area of translation concerns research aimed at enhancing the adoption of best practices in the community~~. ~~Cost-effectiveness of prevention and treatment strategies is also an important part of~~ translational ~~research.~~		1. "integrated solutions to manage the: (i) logistics, (ii) data integration, and (iii) collaboration, and (iv] knowledge generation required by translational investigators and their supporting institutions."
			<ref name="NDNAnderson">{{cite web \|url=http://www.neurodevnet.ca/sites/default/files/neurodevnet/download/Anderson_NeuroDevNet_0103.ppt \|archiveurl=https://web.archive.org/web/20140323010951/http://www.neurodevnet.ca/sites/default/files/neurodevnet/download/Anderson_NeuroDevNet_0103.ppt \|format=PPT \|title=Pragmatic translational informatics: Supporting collaborative science \|author=Anderson, Nicholas \|publisher=NeuroDevNet \|date=2013 \|archivedate=23 March 2013 \|accessdate=23 March 2013}}</ref>

	~~== Overview of Translational Research Informatics ==~~		...or in more lengthy terms:

	~~'''Translational Research Informatics''' can be described as “An integrated software solution~~ to ~~manage~~ the: (~~i) logistics~~, ~~(ii) data integration~~, and ~~(iii~~) ~~collaboration~~, ~~required by translational investigators~~ and ~~their supporting institutions.” It is~~ the ~~class~~ of ~~informatics systems~~ that ~~sits between~~ and ~~often interoperates with~~: ~~(i) Health Information Technology~~/~~[[Electronic Medical Record]] systems~~, ~~(ii) CTMS~~/~~Clinical Research Informatics, and (iii) statistical analysis and [[data mining]]~~.		2. "the informatics subdiscipline that is primarily concerned with the development and application of biomedical informatics theories, methods, and best practices intended to support: 1) the acquisition of knowledge and information from the preceding sources; 2) the representation of such knowledge and information in an actionable format (e.g., readily consumed and analyzed, usually through the use of computational tools and applications), and the subsequent dissemination of that knowledge or information to targeted end-users or analytical platforms; and 3) the semantic integration of disparate data sources to support the discovery and verification/validation of complex bio-marker-to-phenotype relationships that may collectively define a translational biomedical knowledge model."<ref name="PayneTI">{{cite journal \|url=http://physiolgenomics.physiology.org/content/39/3/131.full \|journal=Physiological Genomics \|year=November 2009 \|volume=39 \|issue=3 \|page=131–140 \|title=Translational informatics: enabling high-throughput research paradigms \|author=Payne, Philip R. O.; Embi, Peter J.; Sen, Chandan K. \|doi=10.1152/physiolgenomics.00050.2009 \|accessdate=22 March 2014}}</ref>

	~~Translational Research Informatics~~ is relatively new, with most ~~CTSA [http://www.ctsaweb.org/] awardee academic medical centers actively acquiring~~ and ~~integrating~~ systems ~~to enable~~ the end-to-end TRI requirements. ~~One advanced TRI system is being implemented at the Windber Research Institute in collaboration with GenoLogics [http~~://www.~~genologics.com] and InforSense. Translational Research Informatics systems are expected to rapidly develop and evolve over the next couple of years~~.		The field is relatively new, with most Clinical and Translational Science Awards (CTSAs) funding and research going into informatics tools and systems enabling the end-to-end TRI requirements.<ref name="CTSATools">{{cite web \|url=https://www.ctsacentral.org/reports/sharing/tools/public \|title=Tool Awareness Project \|publisher=CTSA \|accessdate=22 March 2014}}</ref>

	== Systems in ~~Translational Research Informatics~~ ==		==Systems in translational informatics==

			The informatics systems involved in translational informatics tend to fall between and often inter-operate with health informatics and [[electronic medical record]] systems, clinical trial management systems, and statistical analysis and data mining tools.

	{\| class="wikitable"		{\| class="wikitable"
	\|-		\|-
	! System ~~Type~~		! System type
	! Description of ~~System~~		! Description of system
	\|-		\|-
	\| Translational ~~Study Management~~		\| Translational study management
	\| Systems to manage investigator lead biomarker validation studies ~~/ outcomes /~~ observational studies.		\| Systems to manage investigator-lead biomarker validation studies and observational studies
	\|-		\|-
	\| Electronic ~~Patient Questionnaires~~		\| Electronic patient questionnaires
	\| Web based forms for capturing participant demographic, condition, treatment, and ~~outcomes~~ information.		\| Web-based forms for capturing participant demographic, condition, treatment, and outcome information
	\|-		\|-
	\| Clinical ~~Information Management~~		\| Clinical information management
	\| Systems to integrate clinical annotations extracted from various ~~sources~~ systems, like [[Health Level 7\|HL7]] ~~Electronic Medical Records~~, ~~Cancer Registries~~, ~~Clinical Data Management Systems, and Clinical~~ [[~~Data Warehouses~~]].		\| Systems to integrate clinical annotations extracted from various source systems, like [[Health Level 7\|HL7]] electronic medical records, cancer registries, clinical [[laboratory information system]]s, and data warehouses
	\|-		\|-
	\| Biorepository ~~Management Systems~~		\| Biorepository management systems
	\| Manage biospecimens ~~derrived~~ from study participants, operating rooms, etc.		\| Manage biospecimens derived from study participants, operating rooms, etc.
	\|-		\|-
	\| [[Laboratory ~~Information Management Systems~~]]		\| [[Laboratory information management system]]s and [[laboratory information system]]s
	\| Systems to manage clinical, analytical, and life sciences core technology laboratories - often ~~conducting~~ [[genomics]], [[proteomics]], metabolomics, molecular imaging, [[peptide synthesis]], [[flow cytometry]]~~, etc.~~		\| Systems to manage clinical, analytical, and life sciences core technology laboratories which often conduct [[genomics]], [[proteomics]], metabolomics, molecular imaging, [[peptide synthesis]], and [[flow cytometry]] activities
	\|-		\|-
	\| Systems ~~Biology~~ / ~~Science Data Management~~		\| Systems biology / science data management
	\| A ~~data base~~ and content management system to archive raw instrument files and database ~~science~~ results data.		\| A database and content management system to archive raw instrument files and database test results and other data
	\|-		\|-
	\| Research ~~Collaboration System~~		\| Research collaboration system
	\| A software solution to enable investigators and their research teams to share project information, results data, and insights.		\| A software solution to enable investigators and their research teams to share project information, results data, and insights
	\|}		\|}

	~~== CTRI Dedicated WIKI ==~~
	Further discussion of this domain can be found at the [http://www.researchinformatics.org/index.php?option=com_mambowiki&page=Main_Page&page_heading=CRI%20Wiki&show_pageheading=1&allowanonymoususers=0 Clinical Research Informatics Wiki (CRI Wiki)], a wiki dedicated to issues in Clinical and Translational Research Informatics.

	==See also==		==See also==
	[[Bioinformatics]]		[[Bioinformatics]]

	== ~~Related Web Sites~~ ==		==Further reading==
	[http://~~www~~.~~researchinformatics~~.~~org ResearchInformatics~~.~~org]<br~~ />
	[http://~~nihroadmap~~.~~nih~~.~~gov~~/ ~~NIH Roadmap]<br~~ />		* {{cite journal \|url=http://jamia.bmj.com/content/19/2/153.full \|journal=Journal of the American Medical Informatics Association \|year=January 2012 \|issue=19 \|page=153–155 \|title=Translational informatics: an industry perspective \|author=Cantor, Michael N. \|doi=10.1136/amiajnl-2011-000588}}
	[~~http~~://~~ctsaweb~~.org/ Clinical and Translational Science Awards]<br />		* {{cite journal \|url=http://physiolgenomics.physiology.org/content/39/3/131.full \|journal=Physiological Genomics \|year=November 2009 \|volume=39 \|issue=3 \|page=131–140 \|title=Translational informatics: enabling high-throughput research paradigms \|author=Payne, Philip R. O.; Embi, Peter J.; Sen, Chandan K. \|doi=10.1152/physiolgenomics.00050.2009}}

			==External sites==
			[https://www.ctsacentral.org/ Clinical and Translational Science Awards]<br />
	[http://www.amia.org American Medical Informatics Association (AMIA)]<br />		[http://www.amia.org American Medical Informatics Association (AMIA)]<br />

			==References==
			<references />

	[[Category:Informatics]]		[[Category:Informatics]]

Shawndouglas: Added internal link.

2012-10-11T19:39:05Z

Added internal link.

← Older revision		Revision as of 19:39, 11 October 2012
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	\|-		\|-
	\| Clinical Information Management		\| Clinical Information Management
	\| Systems to integrate clinical annotations extracted from various sources systems, like ~~HL7~~ [[Electronic Medical Records]], Cancer Registries, Clinical Data Management Systems, and Clinical [[Data Warehouses]].		\| Systems to integrate clinical annotations extracted from various sources systems, like [[Health Level 7\|HL7]] Electronic Medical Records, Cancer Registries, Clinical Data Management Systems, and Clinical [[Data Warehouses]].
	\|-		\|-
	\| Biorepository Management Systems		\| Biorepository Management Systems

Shawndouglas: Added cat.

2011-11-22T21:54:35Z

Added cat.

← Older revision		Revision as of 21:54, 22 November 2011
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	[http://ctsaweb.org/ Clinical and Translational Science Awards]<br />		[http://ctsaweb.org/ Clinical and Translational Science Awards]<br />
	[http://www.amia.org American Medical Informatics Association (AMIA)]<br />		[http://www.amia.org American Medical Informatics Association (AMIA)]<br />

			[[Category:Informatics]]

Shawndouglas: Recreated article due to necessary redirect.

2011-11-22T21:07:38Z

Recreated article due to necessary redirect.

New page

''(This article was taken from Wikipedia)''

'''Translational Research Informatics''' (TRI) is a sister domain to or a sub-domain of Biomedical informatics or Medical Informatics concerned with the application of [[Informatics (academic field)|informatics]] theory and methods to translational research. There is some overlap with the related domain of Clinical Research Informatics, but TRI is more concerned with enabling multi-disciplinary research to accelerate clinical outcomes, with clinical trials often being the natural step beyond translational research.

Translational Research as defined by the National Institutes of Health [http://www.nih.gov/] includes two areas of translation. One is the process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans. The second area of translation concerns research aimed at enhancing the adoption of best practices in the community. Cost-effectiveness of prevention and treatment strategies is also an important part of translational research.

== Overview of Translational Research Informatics ==

'''Translational Research Informatics''' can be described as “An integrated software solution to manage the: (i) logistics, (ii) data integration, and (iii) collaboration, required by translational investigators and their supporting institutions.” It is the class of informatics systems that sits between and often interoperates with: (i) Health Information Technology/[[Electronic Medical Record]] systems, (ii) CTMS/Clinical Research Informatics, and (iii) statistical analysis and [[data mining]].

Translational Research Informatics is relatively new, with most CTSA [http://www.ctsaweb.org/] awardee academic medical centers actively acquiring and integrating systems to enable the end-to-end TRI requirements. One advanced TRI system is being implemented at the Windber Research Institute in collaboration with GenoLogics [http://www.genologics.com] and InforSense. Translational Research Informatics systems are expected to rapidly develop and evolve over the next couple of years.

== Systems in Translational Research Informatics ==

{| class="wikitable"
|-
! System Type
! Description of System
|-
| Translational Study Management
| Systems to manage investigator lead biomarker validation studies / outcomes / observational studies.
|-
| Electronic Patient Questionnaires
| Web based forms for capturing participant demographic, condition, treatment, and outcomes information.
|-
| Clinical Information Management
| Systems to integrate clinical annotations extracted from various sources systems, like HL7 [[Electronic Medical Records]], Cancer Registries, Clinical Data Management Systems, and Clinical [[Data Warehouses]].
|-
| Biorepository Management Systems
| Manage biospecimens derrived from study participants, operating rooms, etc.
|-
| [[Laboratory Information Management Systems]]
| Systems to manage clinical, analytical, and life sciences core technology laboratories - often conducting [[genomics]], [[proteomics]], metabolomics, molecular imaging, [[peptide synthesis]], [[flow cytometry]], etc.
|-
| Systems Biology / Science Data Management
| A data base and content management system to archive raw instrument files and database science results data.
|-
| Research Collaboration System
| A software solution to enable investigators and their research teams to share project information, results data, and insights.
|}

== CTRI Dedicated WIKI ==
Further discussion of this domain can be found at the [http://www.researchinformatics.org/index.php?option=com_mambowiki&page=Main_Page&page_heading=CRI%20Wiki&show_pageheading=1&allowanonymoususers=0 Clinical Research Informatics Wiki (CRI Wiki)], a wiki dedicated to issues in Clinical and Translational Research Informatics.

==See also==
[[Bioinformatics]]

== Related Web Sites ==
[http://www.researchinformatics.org ResearchInformatics.org]<br />
[http://nihroadmap.nih.gov/ NIH Roadmap]<br />
[http://ctsaweb.org/ Clinical and Translational Science Awards]<br />
[http://www.amia.org American Medical Informatics Association (AMIA)]<br />