https://www.limswiki.org/index.php?action=history&feed=atom&title=File%3AFig5_Naulaerts_BioAndBioInsights2016_10.png 2026-04-05T18:12:41Z Revision history for this page on the wiki MediaWiki 1.36.1 https://www.limswiki.org/index.php?title=File:Fig5_Naulaerts_BioAndBioInsights2016_10.png&diff=27379&oldid=prev 2016-08-24T18:57:52Z

<p><span dir="auto"><span class="autocomment">Summary: </span> Text</span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:57, 24 August 2016</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Summary==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Summary==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Information</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Information</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|Description='''Figure 5.''' Frequent itemsets were mapped to a Cytoscape network that displays which domains are often found to be associated in interacting proteins. The width of the edges indicates the betweenness centrality, while the node size is representative of the degree of the node. Central in this network seem to be IPR001452 (SH3 domain), IPR013783 (immunoglobulin-like fold), and IPR027417 (P-loop NTPase), which is the most prevalent domain in nucleotide-binding proteins. However, the items IPR011009 and IPR000719 were present in the highest number of distinct itemsets. These terms refer to the protein kinase-like domain and the protein kinase domain, respectively, and their importance supports the observations made in Figure 4 that indicate kinase interactions form a vast part of the human interactome. It is interesting to note that of the 1753 proteins featuring a WD40/YVTN repeat-<del style="font-weight: bold; text-decoration: none;">likecontaining </del>domain (IPR015943) in human beings, only associations with the kinase domain (IPR000719) and the kinase-like domain (IPR011009) were retained. The concanavalin A-like lectin/glucanases superfamily (IPR008985) is also shown to have a relatively high centrality in this network.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|Description='''Figure 5.''' Frequent itemsets were mapped to a Cytoscape network that displays which domains are often found to be associated in interacting proteins. The width of the edges indicates the betweenness centrality, while the node size is representative of the degree of the node. Central in this network seem to be IPR001452 (SH3 domain), IPR013783 (immunoglobulin-like fold), and IPR027417 (P-loop NTPase), which is the most prevalent domain in nucleotide-binding proteins. However, the items IPR011009 and IPR000719 were present in the highest number of distinct itemsets. These terms refer to the protein kinase-like domain and the protein kinase domain, respectively, and their importance supports the observations made in Figure 4 that indicate kinase interactions form a vast part of the human interactome. It is interesting to note that of the 1753 proteins featuring a WD40/YVTN repeat-<ins style="font-weight: bold; text-decoration: none;">like-containing </ins>domain (IPR015943) in human beings, only associations with the kinase domain (IPR000719) and the kinase-like domain (IPR011009) were retained. The concanavalin A-like lectin/glucanases superfamily (IPR008985) is also shown to have a relatively high centrality in this network.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Source={{cite journal |title=Practical approaches for mining frequent patterns in molecular datasets |journal=Bioinformatics and Biology Insights |author=Naulaerts, S.; Moens, S.; Engelen, K.; Vanden Berghe, W.; Goethals, B.; Laukens, K.; Meysman, P. |volume=10 |pages=37–47 |year=2016 |doi=10.4137/BBI.S38419 |pmid=27168722 |pmc=PMC4856181}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Source={{cite journal |title=Practical approaches for mining frequent patterns in molecular datasets |journal=Bioinformatics and Biology Insights |author=Naulaerts, S.; Moens, S.; Engelen, K.; Vanden Berghe, W.; Goethals, B.; Laukens, K.; Meysman, P. |volume=10 |pages=37–47 |year=2016 |doi=10.4137/BBI.S38419 |pmid=27168722 |pmc=PMC4856181}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Author=Naulaerts, S.; Moens, S.; Engelen, K.; Vanden Berghe, W.; Goethals, B.; Laukens, K.; Meysman, P.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Author=Naulaerts, S.; Moens, S.; Engelen, K.; Vanden Berghe, W.; Goethals, B.; Laukens, K.; Meysman, P.</div></td></tr> <!-- diff cache key limswiki:diff::1.12:old-27378:rev-27379 --> </table>

Shawndouglas https://www.limswiki.org/index.php?title=File:Fig5_Naulaerts_BioAndBioInsights2016_10.png&diff=27378&oldid=prev 2016-08-24T18:55:08Z

<p>Added summary.</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:55, 24 August 2016</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Summary==</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Information</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|Description='''Figure 5.''' Frequent itemsets were mapped to a Cytoscape network that displays which domains are often found to be associated in interacting proteins. The width of the edges indicates the betweenness centrality, while the node size is representative of the degree of the node. Central in this network seem to be IPR001452 (SH3 domain), IPR013783 (immunoglobulin-like fold), and IPR027417 (P-loop NTPase), which is the most prevalent domain in nucleotide-binding proteins. However, the items IPR011009 and IPR000719 were present in the highest number of distinct itemsets. These terms refer to the protein kinase-like domain and the protein kinase domain, respectively, and their importance supports the observations made in Figure 4 that indicate kinase interactions form a vast part of the human interactome. It is interesting to note that of the 1753 proteins featuring a WD40/YVTN repeat-likecontaining domain (IPR015943) in human beings, only associations with the kinase domain (IPR000719) and the kinase-like domain (IPR011009) were retained. The concanavalin A-like lectin/glucanases superfamily (IPR008985) is also shown to have a relatively high centrality in this network.</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|Source={{cite journal |title=Practical approaches for mining frequent patterns in molecular datasets |journal=Bioinformatics and Biology Insights |author=Naulaerts, S.; Moens, S.; Engelen, K.; Vanden Berghe, W.; Goethals, B.; Laukens, K.; Meysman, P. |volume=10 |pages=37–47 |year=2016 |doi=10.4137/BBI.S38419 |pmid=27168722 |pmc=PMC4856181}}</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|Author=Naulaerts, S.; Moens, S.; Engelen, K.; Vanden Berghe, W.; Goethals, B.; Laukens, K.; Meysman, P.</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|Date=2016</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|Permission=[https://creativecommons.org/licenses/by/3.0/ Creative Commons Attribution 3.0 Unported]</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">}}</ins></div></td></tr> <tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Licensing ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Licensing ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{cc-by-3.0}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{cc-by-3.0}}</div></td></tr> </table>

Shawndouglas https://www.limswiki.org/index.php?title=File:Fig5_Naulaerts_BioAndBioInsights2016_10.png&diff=27377&oldid=prev 2016-08-24T18:53:40Z

<p></p> <p><b>New page</b></p><div>== Licensing ==<br /> {{cc-by-3.0}}</div>

Shawndouglas